Inhibition of anti-CD3 antibody induced serum IL-2 production in mice in vivo by 50 mg/kg of compound 3

August 16, 2024

• Title:       

  Inhibition of anti-CD3 antibody induced serum IL-2 production in mice in vivo by 50 mg/kg of compound 3

• Image Source:

  Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

• Mark:

  Figure 2

• Associated context:

  Compound 3 was tested for its ability to inhibit IL-2 production in vivo in mice following intravenous injection of anti-CD3 antibody (Fig. 2). A 50% inhibition of serum IL-2 production was observed at a dose of 50 mg/kg, sc, irrespective of the amount of the antibody used.