Selective reduction by some vasodilators and the prostaglandin antagonist SC-19220 of a response to the algesic effect of bradykinin

Add time:08/15/2019    Source:sciencedirect.com

The isolated perfused ear of the rabbit connected to the body only by its nerve was used to investigate the influence of some vasodilators (papaverine, aminophylline, NaNO2, verapamil) and a prostaglandin antagonist, SC-19220, on the algesic effect of bradykinin and acetylcholine. Infusion of SC-19220 (3 μg/ml), papaverine (20 μg/ml), aminophylline (100 μg/ml) and NaNO2 (1 mg/ml) selectively reduced the algesic effect of bradykinin but not that of acetylcholine. During inhibition of PG biosynthesis by indomethacin, SC-19220, NaNO2 and aminophylline no longer reduced the bradykinin effect. But these drugs as well as papaverine antagonized the pain-enhancing action of additionally administered PGE1 or PGI2. Verapamil at 1 μg/ml selectively attenuated the effect of bradykinin and at 5 μg/ml reduced both the effect of bradykinin and acetylcholine. The results suggest a differential effect of the vasodilators used on distinct paravascular pain receptors for bradykinin and acetylcholine. It is concluded that SC-19220, NaNO2 and aminophylline act by antagonizing the pain-enhancing action of endogenously released PGs whereas papaverine in addition also reduces the proper effect of bradykinin. Verapamil appears to reduce the bradykinin effect by inhibiting the release of pain-enhancing prostaglandins. The effect of acetylcholine seems to be reduced mainly by an unspecific, local anaesthetic action.

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