Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E1 and leukocytic pyrogen in the cat

Add time:08/17/2019    Source:sciencedirect.com

Intravenous injection of SC-19220 (3–9 mg/kg) caused dose-related hypothermic responses in cats. Repeated administration of SC-19220 resulted in tolerance to its hypothermic action. During SC-19220-induced hypothermia, the hyperthermic activity of both prostaglandin E1 and leukocytic pyrogen was reduced or abolished. Neither prostaglandin E1 nor leukocytic pyrogen was antagonized when given shortly after recovery from SC-19220-induced hypothermia or by doses of SC-19220 which did not cause hypothermia. Although these results may indicate a role of prostaglandins in normal physiological thermoregulation, it is also possible that production of hypothermia by SC-19220 is unrelated to prostaglandin antagonism.

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