Assay of urinary 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9): two methodologies compared

Add time:08/21/2019    Source:sciencedirect.com

Udenfriend's (Sjoerdsma A, Weissbach H, Udenfriend S. J Am Med Assoc 1955; 159: 397) classical screening method for urinary 5-hydroxyindole-3-acetic acid (5-HIAA) is known to be subject to error due to food and drug interferences. Goldenberg (Goldenberg H. Clin Chem 1973; 19: 38–44) introduced a more specific and sensitive method, which has recently been modified by Zouheir Habbal (Zouheir Habbal M. Clin Chim Acta 1983; 130: 251–256). The latter method is shown to correlate fairly well with a high-pressure liquid chromatography (HPLC) method in the 0–100 μmol/24 h range (reference values up to 34 μmol/24 h). It is suggested that elevated values in Udenfriend's screening method can be reliably checked by applying either method.

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