Regular ArticleCascade post-polymerization modification of single pentafluorophenyl ester-bearing homopolymer as a facile route to redox-responsive nanogels

Add time:09/08/2019    Source:sciencedirect.com

Poly(pentafluorophenyl methacrylate) (PPFPMA) was first subjected to post-polymerization modification with oligo(ethylene glycol) methyl ether amine (OEG-NH2) and yielded poly(pentafluorophenyl methacrylate)-co-poly(oligo(ethylene glycol methacrylamide)), PPFPMA-co-POEGMAM. These amphiphilic random copolymers can self-assemble into micellar nanoparticles in water having sizes less than 100 nm. By tandemly reacting the pentafluorophenyl (PFP) groups in the copolymeric nanoparticles with a dithiol crosslinker, cystamine, redox-responsive nanogels can be formed. The last step of post functionalization with isopropylamine was introduced in order to remove the remaining PFP groups in the nanogels. Stepwise post functionalization can be monitored by FTIR and 19F NMR spectroscopy. Release of a model hydrophobic drug, nile red (NR) from the nanogels, simultaneously encapsulated during micelles formation, can be accelerated in the presence of glutathione (GSH) especially at 37 °C. Results from cytocompatibility evaluation suggested that these developed redox-responsive nanogels strongly possessed a potential for applications in controlled delivery.

We also recommend Trading Suppliers and Manufacturers of PENTAFLUOROPHENYL METHACRYLATE (cas 13642-97-2). Pls Click Website Link as below: cas 13642-97-2 suppliers

Prev:Optical and thermal properties of methyl methacrylate and PENTAFLUOROPHENYL METHACRYLATE (cas 13642-97-2) copolymer: Design of copolymers for low-loss optical fibers for gigabit in-home communications
Next:Synthesis of poly[1,1,1,3,3,3-hexafluoro-2-(pentafluorophenyl)propan-2-yl methacrylate]: Thermal and optical properties of the copolymers with methyl methacrylate)