Strychnine-induced seizures in mice: The role of noradrenaline

Add time:09/30/2019    Source:sciencedirect.com

Amabeoku, George and Raymond Chandomba: Strychnine-induced seizures in mice: the role of noradrenaline. Prog. Neuro-psyohopharmacol. & Biol. Psychiat. 1994, 18: 3 753–763.1. The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice.2. Strychnine (0.5–4 mg/kg,i.p.) dose-dependently produced tonic seizures.3. DOPS (4–8 mg/kg,i.p.) significantly shortened the latency of seizures elicited by strychnine (2 mg/kg,i.p.). Similarly, DOPS (4 mg/kg,i.p.) effectively increased the incidence and significantly shortened the latency of seizures induced by strychnine (1 mg/kg, i.p.).4. Imipramirie (20–40 mg/kg, i.p.) and pargyline (200 mg/kg i.p.) significantly shortened the latency of strychnine (2 mg/kg i.p.)-induced seizures.5. Phentolamine (5–20 mg/kg, i.p.) effectively antagonised the seizures elicited by strychnine (2 mg/kg, i.p.). Furthermore, phentolamine (10 mg/kg i.p.) attenuated the seizure-potentiating effect of DOPS (4 mg/kg, i.p.).6. Propranolol (0.5–2 mg/kg, i.p.) and prazosin (1–2 mg/kg, i.p.) reduced the incidence and significantly delayed the latency of seizures induced by strychnine (2 mg/kg i.p.).7. Reserpine (5–10 mg/kg, i.p.) significantly prolonged the latency of strychnine (2 mg/kg, i.p.)-induced seizures.8. Clonidino (0.25–1 mg/kg, i.p.) dose-dependently and significantly antagonised strychnine (2 mg/kg, i.p.). induced seizures.9. Idazoxan (1–4 mg/kg, i.p.) in a dose related manner significantly shortened the latency of seizures induced by strychnine (2 mg/kg, i.p.). Similarly, idazoxan (2 mg/kg, i.p.) profoundly potentiated seizures elicited by strychnine (1 mg/kg, i.p.). 1dazoxan (4 mg/kg, i.p.) significantly antagonised the protective effect of clonidine (1 mg/kg, i.p,) against strychnine (2 mg/kg, i.p.)-induced seizures.10. Disulfiram (3 × 25 − 3 × 100 mg/kg. i.p.) significantly attenuated strychnine (2 mg/kg, i.p.)-induced seizures. DOPS (4 mg/kg, i.p.) significantly potentiated strychnine seizures in disu1firam (3 × 100 mg/kg, i.p.)-pretreated animals.11. These results indicate that enhancement of noradrenergic neurotransmission potentiates strychnine seizures in mice.

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