Reference

Hydrogel dosage form of the drug combination recently introduced for dental post-extraction complications

Hydrogel dosage form of the drug combination recently introduced for dental post-extraction complications. Turakka, Liisa; Syrjanen, Stina; Lammi, Juba; Syrjanen, Kari (Dep. Pharm. Technol., Univ. Kuopio, Kuopio, Finland). Acta Pharm. Fenn., 95(2), 77-81 (English) 1986. CODEN: APHFDO. ISSN: 0356-3456. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Properties such as consistency, stability in water, and water and blood absorbance, of 8 gelling agents and hydrogels were tested. Only Carbopol 934 [9007-16-3] and hydroxypropyl Me cellulose (HPMC) [9004-65-3] had the required properties useful for prepg. a dosage form of the drug combination of cincaine chloride [61-12-1], CHI3 [75-47-8], tranexamic acid [1197-18-8], and Pr p-hydroxybenzoic acid [94-13-3] introduced for dental post-extn. complications. Carbopol 934 at 7% and HPMC at 8% were the most suitable concns. for the formulations. The consistency and adherence of both the hydrogels were similar. Carbopol was stable in water longer and absorbed more water than HPMC.

Metabolism of haloforms to carbon monoxide

Metabolism of haloforms to carbon monoxide. I. In vitro studies. Ahmed, A. E.; Kubic, V. L.; Anders, M. W. (Dep. Pharmacol., Univ. Minnesota, Minneapolis, Minn., USA). Drug Metab. Dispos., 5(2), 198-204 (English) 1977. CODEN: DMDSAI. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Trihalomethanes (haloforms) were metabolized to CO by a rat liver microsomal fraction requiring both NADPH and mol. O for max. activity. GSH alone did not serve as a cofactor; however, GSH in the presence of NADPH and O produced an 8-fold increase in the metab. of bromoform [75-25-2] to CO. Similar results were obtained with other sulfhydryl compds. The bioconversion of bromoform to CO was characterized with respect to time course, microsomal protein concn., pH and temp. Iodoform [75-47-8] yielded the greatest amt. of CO, whereas chloroform [67-66-3] yielded the smallest amt. Haloforms are apparently metabolized to CO via a cytochrome P-450-dependent mixed-function oxidase system.