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| CAS No.: | 26787-78-0 |
|---|---|
| Name: | Amoxicillin |
| Molecular Structure: | |
|
|
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| Formula: | C16H19N3O5S |
| Molecular Weight: | 365.41 |
| Synonyms: | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-, D- (8CI);Eupensol;Excillin;Farconcil;Fisamox;Foxolin;Fullcilina;Gemox;Gimalxina;Gomcillin;Gramidil;Grunamox;Hiconcil;Hipen;Histocillin;Hosboral;Imacillin;Imaxilin;Imox;Imoxil;Intermox;Jerramcil;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, [2S-[2a,5a,6b(S*)]]-;6-[D-(-)-p-Hydroxy-a-aminobenzyl]penicillin;6-[D-a-Amino-a-(4-hydroxyphenyl)acetamido]penicillanicacid;A-Gram;Actimoxi;Agerpen;Alfamox;Almodan;Alphamox;Amagesen Solutab;Amodex;Amoflux;Amopenixin;Amoxa;Amoxal;Amoxapen;Amoxaren;Amoxi;Amoxi-Mast;Amoxicilina;Amoxidal;Amoxiden;Amoxil;Amoxin;Amoxipen;Amoxtrex;Amoxy;Amoxypen;Ampidroxyl;Ampy-Penyl;Anemol;Anemolin;Apitart;Apo-Amoxi;Ardine;Aspenil;Audumic;BLP1410;BRL 2333;Bactox;Betamox;Bimox;Biomox;Bioxidona;Bioxyllin;Cabermox;Cilamox;Clamox;Clamoxyl;Coamoxin;Comoxyl;D-(-)-a-Amino-p-hydroxybenzyl penicillin;D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid;D-Amoxicillin;Delacillin;Efpenix;Efpinex;Eupen; |
| EINECS: | 248-003-8 |
| Density: | 1.54 g/cm3 |
| Melting Point: | 140 °C |
| Boiling Point: | 743.2 °C at 760 mmHg |
| Flash Point: | 403.3 °C |
| Solubility: | 4g/L at 25℃ |
| Appearance: | solid |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 42/43 |
| Safety: | 22-36/37 |
| PSA: | 158.26000 |
| LogP: | 1.05280 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In methanol; water for 3h; | 62% |
- 551-16-6
6-Aminopenicillanic Acid
- 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| at 30℃; for 3h; Pseudomonas melanogenum KY 3987 and KY 8540; Yield given; | |
| With penicillin acylasefrom Escherichia coli; water |
- 551-16-6
6-Aminopenicillanic Acid
- 57591-61-4, 68697-60-9, 127369-30-6, 134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| With iso-butanol In water at 20℃; Xanthomonas citri K24, pH = 6-7; Yield given; |
| Conditions | Yield |
|---|---|
| In sodium amoxycillin; water; amoxycillin trihydrate; cefaclor monohydrate |
- 7732-18-5
water
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide In acetone |
- 32462-30-9
(S)-hydroxyphenylglycine
- 3282-30-2
pivaloyl chloride
- 141-97-9
ethyl acetoacetate
- 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| With triethylamine In ethanol; dichloromethane |
- 82095-48-5, 95510-67-1
D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt
- 3282-30-2
pivaloyl chloride
- 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid
- 26787-78-0
amoxicillin
| Conditions | Yield |
|---|---|
| In dichloromethane; ISOPROPYLAMIDE; water |
- 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid
- 26787-78-0
amoxicillin
- 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid
A
- 26787-78-0
amoxicillin
B
- 760-67-8
2-ethylhexanoic acid chloride
- 551-16-6, 1079-37-4, 3115-55-7, 21794-93-4, 145920-51-0
6-aminopenicillanic acid
- 10416-58-7
N,N-bis(trimethylsilyl)acetamide
- 26787-78-0
amoxicillin
- 15826-37-64H-1-Benzopyran-2-carboxylicacid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, sodium salt (1:2)
- 98-73-74-tert-Butylbenzoic acid
- 77-06-5Gibberellic acid
- 3710-84-7Ethanamine,N-ethyl-N-hydroxy-
- 521-18-6Androstan-3-one,17-hydroxy-, (5a,17b)-
- 127-19-5N,N-Dimethylacetamide
- 87-66-1Pyrogallol
- 41340-25-4Etodolac
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
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Chemistry
Structure of Amoxicillin (CAS NO.26787-78-0):
IUPAC Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Empirical Formula: C16H19N3O5S
Molecular Weight: 365.4042
EINECS: 248-003-8
Index of Refraction: 1.701
Molar Refractivity: 91.47 cm3
Molar Volume: 236.2 cm3
Polarizability: 36.26×10-24cm3
Surface Tension: 85.3 dyne/cm
Density: 1.54 g/cm3
Flash Point: 403.3 °C
Enthalpy of Vaporization: 113.73 kJ/mol
Boiling Point: 743.2 °C at 760 mmHg
Vapour Pressure: 3.39E-23 mmHg at 25°C
Stability: Stable. Incompatible with strong oxidizing agents.
Product Categories: Antibiotics;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity
Uses
Amoxicillin can be used as broad-spectrum semi-synthetic PENICILLIN. It is active against gram-positive and -negative bacteri. Clinic for the treatment of tonsillitis, laryngitis, pneumonia, chronic bronchitis, urinary tract infections, skin and soft tissue infections, septic pleurisy, hepatobiliary system infections, sepsis, typhoid, dysentery. The antimicrobial spectrum of goods for drugs, and its role and application of both PENICILLIN and Benzyl chloride similar strengths of the serum protein binding rate and blood concentration more than twice as high as ampicillin.
Production
6-APA and N-(3-ethoxycarbonyl-1-methyl vinyl) Sodium p-hydroxyphenylglycine derived by condensation. 6- APA is the production of a wide range of semi-synthetic PENICILLIN important raw materials. Large industrial use of microorganisms PENICILLIN lactamase cracker natural PENICILLIN (PENICILLIN G or PENICILLIN V) approach to the admission system.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 300mg/kg (300mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: HEMATURIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Clinical Pediatrics Vol. 32, Pg. 735, 1993. |
| child | TDLo | oral | 682mg/kg (682mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: HEMATURIA | Clinical Pediatrics Vol. 32, Pg. 735, 1993. |
| man | TDLo | oral | 7143ug/kg (7.143mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Allergy. Vol. 52(Suppl, |
| man | TDLo | oral | 40mg/kg/4D (40mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES | Lancet. Vol. 2, Pg. 707, 1978. |
| mouse | LD50 | intracrebral | > 500mg/kg (500mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS | Chemotherapy Vol. 26, Pg. 196, 1980. |
| mouse | LD50 | intraperitoneal | 3590mg/kg (3590mg/kg) | Drugs in Japan Vol. -, Pg. 59, 1990. | |
| mouse | LD50 | oral | > 25gm/kg (25000mg/kg) | Drugs in Japan Vol. 6, Pg. 38, 1982. | |
| mouse | LD50 | subcutaneous | > 20mg/kg (20mg/kg) | Drugs in Japan Vol. -, Pg. 59, 1990. | |
| rat | LD50 | intraperitoneal | 2870mg/kg (2870mg/kg) | Drugs in Japan Vol. -, Pg. 59, 1990. | |
| rat | LD50 | oral | > 15gm/kg (15000mg/kg) | Drugs in Japan Vol. 6, Pg. 38, 1982. | |
| rat | LD50 | subcutaneous | > 8gm/kg (8000mg/kg) | Drugs in Japan Vol. -, Pg. 59, 1990. |
Safety Profile
Hazard Codes : 
Xn,
Xi
Risk Statements : 42/43
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements : 22-36/37
S22:Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
WGK Germany : 2
RTECS : XH8300000
Standards and Recommendations
Purity of amoxicillin: 98.00%
Specification
Amoxicillin , its cas register number is 26787-78-0. It also can be called 6-(D-(-)-alpha-Amino-p-hydroxyphenylacetamido)penicillanic acid ; 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin ; 6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid ; Amoclen ; Amolin ; Amopenixin ; Amoxi ; Amoxi-Mast ;Amoxicaps ; Amoxicilina ; Amoxicillin pediatric ; Amoxicilline ; Amoxicillinum Amoxiden ; Amoxil ; Amoxivet ; D-(-)-alpha-Amino-p-hydroxybenzylpenicillin ; D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid ; D-Amoxicillin ; Delacillin ; DisperMox ; Hiconcil ; Histocillin ; Ibiamox ; Imacillin ; Larotid ; Metafarma capsules ; Metifarma capsules ; Moxacin ; Moxal ; Wymox ; alpha-Amino-p-hydroxybenzylpenicillin ; p-Hydroxyampicillin .