16347-60-7

Basic information

• Product Name: 3-PHENYL-4-[3H]QUINAZOLINONE
• Synonyms: 4-KETO-3-PHENYL-3,4-DIHYDROQUINAZOLINE;3-PHENYL-4(3H)-QUINAZOLINE;3-PHENYL-4-[3H]QUINAZOLINONE;PhenylHquinazolinone;3-phenyl-3,4-dihydroquinazolin-4-one;3-Phenylquinazolin-4(3H)-one;3-Phenyl-4-quinazolinone;3-Phenyl-4-quinazolone
• CAS NO: 16347-60-7
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.24
• Product Categories: quinazolinone
• Mol File: 16347-60-7.mol

Chemical Properties

• Melting Point: 138-140°C
• Boiling Point: 391.1 °C at 760 mmHg
• Flash Point: 190.3 °C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 2.53E-06mmHg at 25°C
• Refractive Index: 1.646
• PKA: 2.00±0.70(Predicted)
• CAS DataBase Reference: 3-PHENYL-4-[3H]QUINAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-4-[3H]QUINAZOLINONE(16347-60-7)
• EPA Substance Registry System: 3-PHENYL-4-[3H]QUINAZOLINONE(16347-60-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 16347-60-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-PHENYL-4-[3H]QUINAZOLINONE is used as a building block for the synthesis of biologically active molecules due to its unique structure and chemical properties. It serves as a key component in the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
3-PHENYL-4-[3H]QUINAZOLINONE is used as a potential drug candidate for various therapeutic applications. Its study contributes to the advancement of medicinal chemistry by exploring its potential as a treatment for different diseases and conditions.
Used in Drug Development:
3-PHENYL-4-[3H]QUINAZOLINONE is utilized in drug development for its potential to be transformed into effective pharmaceuticals. 3-PHENYL-4-[3H]QUINAZOLINONE's unique attributes make it a valuable asset in the creation of novel therapeutic agents that could address unmet medical needs.

InChI:InChI=1/C14H10N2O/c17-14-12-8-4-5-9-13(12)15-10-16(14)11-6-2-1-3-7-11/h1-10H

Upstream product

• 127662-21-9 3-phenyl-1,2,3,4-tetrahydroquinazoline 
• 118-92-3 anthranilic acid 
• 864131-95-3 N,N'-diphenylformamidine 
• 103-70-8 Formanilid 
• 134-20-3 2-carbomethoxyaniline 
• 4424-17-3 2-aminobenzanilide 
• 64-18-6 formic acid 
• 2032-24-8 N,N'-di(p-chlorophenyl)formamidine 
• 77287-34-4 formamide 
• 118-48-9 isatoic anhydride 
• 62-53-3 aniline 
• 124-38-9 carbon dioxide 
• 50-00-0 formaldehyd 
• 15310-01-7 benodanil 

Downstream Products

• 127662-21-9 3-phenyl-1,2,3,4-tetrahydroquinazoline 
• 859963-94-3 N-(1,3-diphenylpropan-2-yl)benzenamine 
• 857580-89-3 2-(1-benzyl-2-phenyl-ethylamino)-5-nitroso-benzoic acid anilide 
• 856355-75-4 N-(1-benzyl-2-phenyl-ethyl)-N-nitroso-anthranilic acid anilide 
• 1011-47-8 1-quinolin-2-yl-ethanone 
• 2385-23-1 2-Methyl-3-phenyl-4(3H)-quinazolinone 
• 1564224-22-1 methyl 3-(4-oxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 
• 1564223-81-9 3-(4-oxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanenitrile 
• 1564224-75-4 tert-butyl 3-(4-oxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 
• 612-97-5 3-phenyl-3,4-dihydro-quinazoline 
• 14663-46-8 3-amino-3,4-dihydroquinazolin-4-one 
• 857580-91-7 N-(1-benzyl-2-phenyl-ethyl)-anthranilic acid anilide 

Relevant articles and documents

Aluminium nitrate-catalyzed one-pot synthesis of 4(3h)-quinazolinones by a three-component coupling of anthranilic acid, amines, and ortho esters

The one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid, amines, and ortho esters in the presence of aluminium nitrate has been carried out. The reaction occurred in a few minutes at room temperature under solvent-free con

Convergent one-pot synthesis of 3-substituted quinazolin-4(3H)-ones under solvent-free conditions

A convenient method for the synthesis of 3-substituted quinazolin-4(3H)- ones using the convergent reactions of formic acid, a primary amine, and isatoic anhydride under solvent-free conditions and with brief microwave irradiation is described. Copyright Taylor & Francis Group, LLC.

Zirconyl(IV) chloride catalyzed three component one-pot synthesis of quinazolin-4(3H)-ones

An efficient one-pot method for synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, triethyl orthoformate, and amines using ZrOCl2 is described. This method offers improvements for the synthesis of quinazolin-4(3H)-ones with r

Dimerization of substituted 2-aminobenzoic acids under Vilsmeier conditions: A novel route to the synthesis of 4-(3H)-quinazolinones

Various substituted 2-aminobenzoic acids on treatment with Vilsmeier reagent (DMF/POCl3) at 80-90°C undergo a novel dimerization reaction to yield 2-[3,4-dihydro-4-oxo-3-quinazolinoyl]-N,N-dimethyl benzamides. The interruption of dimerization a

Facile synthesis of substituted quinazolin-4-(3H)-ones using low-valence titanium reagent

A short and facile synthesis of a series of 3-aryl quinazolin-4-(3H)-ones was accomplished in good yields via the intermolecular reductive coupling reaction of N-aryl-2-nitrobenzamide and triethyl orthoformate promoted by TiCl4/Zn.

Synthesis of 3-Aryl-4(3H)-quinazolinones from anthranilic acid, ortho esters, and anilines using Ce(CH3SO3)3· 2H2O as catalyst

3-Aryl-4(3H)-quinazolinones were synthesized efficiently by the three component one-pot cyclocondensation of anthranilic acid, ortho esters, and anilines in the presence of Ce(CH3SO3)3·2H 2O at room temperature under solve

SnCl2·2H2O-catalyzed one-pot synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters, and amines under solvent free conditions

(Chemical Equation Presented) A simple, efficient, and green procedure for the one-pot synthesis of 4(3H)-quinazolinones by three components condensation of anthranilic acid, ortho esters, and amines in the presence of SnCl 2·2H2O ha

Synthesis of Quinazolinones, Imidazo[1,2-c]quinazolines and Imidazo[4,5-c]quinolines through Tandem Reductive Amination of Aryl Halides and Oxidative Amination of C(sp3)–H Bonds

A tandem multicomponent approach has been described for the synthesis of quinazolinones, imidazo[1,2-c]quinazolines and imidazo[4,5-c]quinolines. The reaction involves a copper-catalyzed reductive amination through azidation followed by reduction and oxidative amination of C(sp3)–H bonds of N,N-dimethylacetamide in the presence of TBHP (tert-butylhydroperoxide) as oxidant. The method uses the easily available sodium azide as a nitrogen source and DMA (N,N-dimethylacetamide) as a one-carbon source for the synthesis of these N-fused heterocycles in good to excellent yields. The reaction can also be used for gram-scale synthesis.

A convenient synthesis of substituted quinazolin-4(3H)-ones under microwave and solvent-free conditions

A clean and facile synthesis of the title compounds is achieved from cyclocondensation of 2-aminobenzamides with orthoesters catalyzed by SiO 2/H2SO4 in dry and microwave conditions.

Synthesis, photochemical and luminescent properties of (E)-2-(2-hydroxyarylethylene)-3-phenylquinazolin-4(3H)-ones

Photoinduced transformations of 2-styrylquinazolinones in solutions were studied using absorption and NMR spectroscopy methods. A possibility of control of the photochemical isomerization rate of quinazolinone 2-(hydroxyaryl)ethenyl derivatives by changin