29632-74-4Relevant articles and documents
METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 69, (2019/02/06)
The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
METALLO-BETA-LACTAMASE INHIBITORS
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Page/Page column 46, (2017/04/04)
The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
Largely blue-shifted emission through minor structural modifications: Molecular design, synthesis, aggregation-induced emission and deep-blue OLED application
Huang, Jing,Sun, Ning,Chen, Pengyu,Tang, Runli,Li, Qianqian,Ma, Dongge,Li, Zhen
supporting information, p. 2136 - 2138 (2014/02/14)
By simply introducing additional groups with different size and conjugation degree to the 2,2′-positions of BTPE, four BTPE derivatives are prepared which give blue or deep-blue EL emissions when used as emitters in non-doped OLEDs, as the result of the tuned dihedral angles of the biphenyl cores (up to ～89°), providing a new approach to design AIE luminogens with blue and deep-blue emissions. The Royal Society of Chemistry.
Polymer-supported organotin reagents for regioselective halogenation of aromatic amines
Chretien, Jean-Mathieu,Zammattio, Francoise,Le Grognec, Erwan,Paris, Michael,Cahingt, Blanche,Montavon, Gilles,Quintard, Jean-Paul
, p. 2870 - 2873 (2007/10/03)
(Chemical Equation Presented) Polymer-supported triorganotin halides were used in the halogenation reaction of aromatic amines. Treatment of aromatic amines with n-butyllithium and polymer-supported organotin halides gave the corresponding polymer-bound N-triorganostannylamines, which by treatment with bromine or iodine monochloride gave the para-halogenated aromatic amines with high yields and high selectivities. The polymer-supported organotin halides reagents regenerated during the course of the halogenation reaction can be reused without loss of efficiency. The presence of tin residues in halogenated aromatic amines was also investigated and evaluated at under 20 ppm after three runs.
PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES
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Page 141, (2010/02/07)
This invention relates to compounds of the formula (1) wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
The synthesis and mesomorphic properties of 2,2′,3-tri- and 2,2′,3,3′-tetra-fluoro-1,1′:4′,1″-terphenyls for high dielectric biaxiality ferroelectric liquid crystal mixtures
Glendenning, Margaret E.,Goodby, John W.,Hird, Michael,Toyne, Kenneth J.
, p. 481 - 491 (2007/10/03)
Liquid crystalline 1,1′:4′,1″-terphenyls with three and four lateral fluoro substituents and alkyl or alkoxy substituents in the 4- and 4′-positions have been synthesised. Synthetic strategies employed were convergent and involved the use of arylboronic acids and aryl halides in palladium-catalysed cross-coupling reactions. These syntheses are of particular interest because issues of selective metallation (at positions ortho to a fluoro substituent) and selective coupling reactions (bromo versus iodo sites) are involved, not all of which proceed as expected. All the trifluoroterphenyls and most of the tetrafluoroterphenyls generate the smectic C phase, the phase stability and temperature range of which were found to be highly dependent upon the relative lengths of the two terminal chains. The 2,2′,3- and 2,2′,3,3′-patterns of lateral fluoro substitution in 1,1′:4′,1″-terphenyls generate materials of high lateral dipole and enable the formulation of ferroelectric mixtures with a high dielectric biaxiality which is very important in τV minimum driving schemes.
Synthesis of further amino-halogen-substituted phenyl-aminoethanols
Kruger,Keck,Noll,Pieper
, p. 1612 - 1624 (2007/10/02)
Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.
