868-18-8

Basic information

• Product Name: Sodium tartrate
• Synonyms: SODIUM L-TARTRATE;SODIUM TARTRATE DIBASIC;[r-(r*,r*)]-2,3-dihydroxybutanedioic acid disodium salt;L-TARTARIC ACID SODIUM SALT;DISODIUM TARTRATE;Butanedioicacid,2,3-dihydroxy-[R-(R*,R*)]-disodiumsalt;sodiumdl-tartrate;SODIUM SULPHATE ANHY
• CAS NO: 868-18-8
• Molecular Formula: C₄H₄O₆*2Na
• Molecular Weight: 194.05
• EINECS: 212-773-3
• Product Categories: Food additive and acidulant
• Mol File: 868-18-8.mol

Chemical Properties

• Boiling Point: 399.3 °C at 760 mmHg
• Flash Point: 209.4 °C
• Appearance: /
• Density: 1.818
• Vapor Pressure: 4.93E-08mmHg at 25°C
• Water Solubility: soluble in ~9 parts H2O, 2 parts boiling H2O; insoluble alcohol [MER06]
• CAS DataBase Reference: Sodium tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium tartrate(868-18-8)
• EPA Substance Registry System: Sodium tartrate(868-18-8)

Safety Data

• Hazardous Substances Data: 868-18-8(Hazardous Substances Data)

Usage

Uses

Used in Food Industry:
Sodium tartrate is used as a food additive, specifically as an emulsifier and binding agent in food products such as jellies, margarine, and sausage casings. It helps to improve the texture and stability of these products. As a food additive, it is identified by the E number E335.
Used in Meat Products and Sausage Casings:
Sodium tartrate functions as a sequestrant and stabilizer in meat products and sausage casings, enhancing their quality and shelf life.
Used in Chemical Industry:
Sodium tartrate is utilized as a reagent and serves as a sequestrant and stabilizer in various chemical applications.
Used in Pharmaceutical Industry:
Due to its precise water capture in its crystal structure, sodium tartrate is a common primary standard for Karl Fischer titration, a technique widely used in the pharmaceutical industry to assay water content in active pharmaceutical ingredients and final products.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2/t1-,2-;;/m1../s1

Synthetic route

D-glucose (50-99-7) → sodium D-gluconate (527-07-1) + sodium tartrate (868-18-8) + D-glucaric acid disodium salt

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium bromide In water at 5℃; pH=11.7;	A n/a B n/a C 90%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium bromide In water at 5℃; pH=11.2; Product distribution; Further Variations:; pH-values; Reaction partners;	A n/a B n/a C 64%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium bromide In water at 5℃; pH=9.5;

Bi(3+)*OH(1-)*C4H4O6(2-)=Bi(OH)C4H4O6 → 3Bi(3+)*7OH(1-)*C4H4O6(2-)=Bi(OH)*C4H4O6*2Bi(OH)3 + sodium tartrate (868-18-8)

Conditions	Yield
In sodium hydroxide solvation in aq. NaOH with formation of Na tartrate and the soluble coordination compound Bi(OH)C4H4O6*2Bi(OH)3;;

sodium hydrogen tartrate *H2O + sodium ethanolate (141-52-6) → sodium tartrate (868-18-8)

Conditions	Yield
In not given contact of NaOC2H5 with NaC4H5O6; slow reaction in the cold, fast reaction in the warmth;;
In not given contact of NaOC2H5 with NaC4H5O6; slow reaction in the cold, fast reaction in the warmth;;

sodium arsenyl tartrate * 2.5H2O + sodium hydroxide (1310-73-2) → arsenic(III) trioxide + sodium tartrate (868-18-8)

Conditions	Yield
In not given formed when neutralized with NaOH; As2O3 pptd. and Na2C4H4O6 remained dissolved;;

sodium tartrate dihydrate → sodium carbonate (497-19-8) + sodium tartrate (868-18-8)

Conditions	Yield
In neat (no solvent) byproducts: H2O, CO2, C; stepwise loss of H2O up to 154°C; decompn. of Na2C4H4O6 starting at 255°C; decompn. to Na2CO3 and C at 309°C: combustion of C up to 700°C; dissociation of Na2CO3 at 875°C;;
In neat (no solvent) byproducts: H2O, CO2, C; stepwise loss of H2O up to 154°C; decompn. of Na2C4H4O6 starting at 255°C; decompn. to Na2CO3 and C at 309°C: combustion of C up to 700°C; dissociation of Na2CO3 at 875°C;;

2Bi(3+)*4H(1+)*5C4H4O6(2-)=Bi2(C4H4O6)3*2C4H6O6 → 3Bi(3+)*7OH(1-)*C4H4O6(2-)=Bi(OH)*C4H4O6*2Bi(OH)3 + sodium tartrate (868-18-8)

Conditions	Yield
With sodium hydroxide In water dissolution in aq. NaOH;;

tartaric acid (87-69-4) → sodium tartrate (868-18-8)

Conditions	Yield
With sodium hydroxide pH=4.9;

sodium oxalate (62-76-0) → sodium tartrate (868-18-8)

Conditions	Yield
With sodium cyanide Alkaline conditions;

sodium dihydroxyfumarate + sodium oxalate (62-76-0) → disodium meso-tartrate (526-94-3, 868-18-8, 4504-50-1, 14475-11-7, 21106-15-0, 21348-52-7, 21595-79-9, 22476-77-3, 25817-08-7, 51307-92-7, 60131-40-0, 64183-71-7, 109175-69-1) + sodium tartrate (868-18-8)

Conditions	Yield
With sodium cyanide; sodium hydroxide for 24h; Aldol Condensation;

sodium tartrate (868-18-8) → micafungin sodium

Conditions	Yield
In ethanol; water	99.53%

chloroform (67-66-3) + ((C4NH2C(C6H4CH3))3H2(C(C6H4CH3)C4NH))2 + zinc(II) acetate dihydrate (5970-45-6) + sodium tartrate (868-18-8) + benzene (71-43-2) → 2Zn(2+)*((CH3C6H4CN)4(CH)7C9H)2(2-)*(OOCCHOH)2(2-)*2C6H6*CHCl3=(Zn2((CH3C6H4CN)4(CH)7C9H)2(OOCCHOH)2)*2C6H6*CHCl3

Conditions

Yield

In methanol; chloroform soln. Zn(AcO)2*2H2O in MeOH was added to soln. ligand in CHCl3, mixt. was stirred for 1 h and evapd. at room temp., solid was dissolved in CHCl3, filtered, filtrate volume was reduced, aq. soln. Na2tart was added, mixt. was stirred for 1 h; org. phase was isolated, washed with water, water phase was filtered, evapd. to dryness, solid was crystd. from benzene/CHCl3/hexane; elem. anal.;

80%

1,10-Phenanthroline (66-71-7) + cobalt(II) nitrate hexahydrate + water (7732-18-5) + sodium tartrate (868-18-8) → [Co(tartrate)(1,10-phenanthroline)]*6H2O

Conditions	Yield
In methanol; water aq. soln. of Co compd. (1 mmol) and H2O/MeOH (1:2) soln. of phen (1 mmol) and sodium tartrate (1 mmol); crystd. on storage for 2 wk, elem. anal.;	74%

[2,2]bipyridinyl (366-18-7) + cobalt(II) nitrate hexahydrate + water (7732-18-5) + sodium tartrate (868-18-8) → [Co(tartrate)(2,2'-bipyridine)]*5H2O

Conditions	Yield
In methanol; water aq. soln. of Co compd. (1 mmol) and H2O/MeOH (1:2) soln. of phen (1 mmol) and sodium tartrate (1 mmol); crystd. on storage for 2 wk, elem. anal.;	70%

Pt(2+)*C12H12N2*2NO3(1-) + water (7732-18-5) + sodium tartrate (868-18-8) → C28H26N4O6Pt2*4H2O

Conditions	Yield
for 6h; Reflux;	68%

(R)-8-Fluoro-5-methoxycarbonyl-3-(N,N-di-n-propylamino)chroman + oxalyl dichloride (79-37-8) + sodium tartrate (868-18-8) → (R)-8-Fluoro-5-formyl-3-(N,N-dipropylamino)-chroman

Conditions	Yield
With sodium hydroxide; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide	60%

Pt(2,2`-bipyridine)(ONO2)2 (54822-51-4) + water (7732-18-5) + sodium tartrate (868-18-8) → [{2,2’-bipyridine platinum(II)}2(μ-D-tart)][{2,2’-bipyridine platinum(II)}2(μ-L-tart)]*4H2O + [2,2’-bipyridine platinum(II)(D-tartH2)][2,2’-bipyridine platinum(II)(L-tartH2)]*4H2O

Conditions	Yield
In water at 20℃; for 24h;	A 54% B 0.5%

di(hexamethyleneimine)(sulfato)aquoplatinum(II) (503590-72-5) + sodium tartrate (868-18-8) → di(hexamethyleneimine)(tartronato)platinum(II)

Conditions	Yield
In water 2 equiv. of Na salt, stirred for 24 h; filtered, concd. (vac.), cooled to 0°C for 24 h, ppt. filtered, washed (cold water), dried (vac.); elem. anal.;	53.48%

1,2-bis(4'-pyridyl)ethane (4916-57-8) + Cu(2+)*2NO3(1-)*8H2O=Cu(NO3)2*8H2O + sodium tartrate (868-18-8) → [Cu3(tartaric acid)(tartaric acid)-(H2O)(1,2-bis(4-pyridyl)ethane)] · 3H2O

Conditions	Yield
With potassium iodide; sodium hydroxide In methanol; water at 150℃; for 96h; Sealed tube;	52%

copper(II) nitrate trihydrate + cucurbit[6]uril + water (7732-18-5) + sodium tartrate (868-18-8) → C36H36N24O12*C18H28N4(2+)*4C4H2O6(4-)*19H2O*7Cu(2+)

Conditions	Yield
In water at 120℃; for 48h; Autoclave;	44%

copper(II) choride dihydrate + cucurbit[6]uril + sodium tartrate (868-18-8) → C36H36N24O12*C18H26N4*2C4H4O6(2-)*2Cl(1-)*2H2O*3Cu(2+)

Conditions	Yield
In water at 120℃; for 48h; Autoclave;	40.6%

C29H54N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C29H54N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	25%

C27H50N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C27H50N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	21%

C26H48N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C26H48N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	20%

C25H46N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C25H46N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	20%

C26H48N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C26H48N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	20%

C24H44N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C24H44N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	18%

C26H48N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C26H48N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	18%

C22H40N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C22H40N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	17%

C25H46N3O(1+)*Br(1-) + sodium tartrate (868-18-8) → C25H46N3O(1+)*0.5C4H4O6(2-)

Conditions	Yield
In dichloromethane	16%

sodium tartrate (868-18-8) → C4(2)H6O6

Conditions	Yield
With sodium hydroxide; water-d2 for 4h; Heating;

ethanol (64-17-5) + diethylaluminium chloride (96-10-6) + sodium tartrate (868-18-8) + ethyl bromoacetate (105-36-2) + 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one (55854-89-2) → ethyl 3-hydroxy-3-(8-methyl-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)pentanoate

Conditions	Yield
With silver(I) acetate; potassium In tetrahydrofuran; dichloromethane
With silver(I) acetate; potassium In tetrahydrofuran; dichloromethane

2S-2-tert-butoxycarbonylamino-4-(2S-3,3-dimethyl-oxiranyl)-butyric acid methyl ester (329270-46-4) + 2S-2-tert-butoxycarbonylamino-4-(2R-3,3-dimethyl-oxiranyl)-butyric acid methyl ester (329270-45-3) + tungsten(VI) chloride (13283-01-7) + sodium tartrate (868-18-8) → (2S)-2-tert-Butoxycarbonylamino-6-methylhept-5-enoic acid methyl ester (329270-44-2)

Conditions	Yield
With sodium hydroxide; n-butyllithium In tetrahydrofuran

methyl N-(pyridin-4-yl)isonipecotate + sodium tartrate (868-18-8) + potassium tartrate → 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2) + C-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methylamine (166954-15-0)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water; ethyl acetate

methyl N-(pyridin-4-yl)isonipecotate + sodium tartrate (868-18-8) + potassium tartrate → N-(5-chloropyridin-2-yl)-2-[[1-(4-pyridinyl)piperidin-4-yl]methoxy]benzamide (725683-58-9) + 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water; ethyl acetate

3,5-dichloro-4-aminopyridine (22889-78-7) + sodium diethylaluminate + 1'-benzotriazolyl 7-methoxy-2-methoxymethyl-3H-benzimidazole-4-carboxylate + sodium tartrate (868-18-8) → N-(3,5-dichloro-pyridin-4-yl)-7-methoxy-2-methoxymethyl-3H-benzimidazole-4-carboxamide (201284-92-6)

Conditions	Yield
In tetrahydrofuran; toluene

methyl N-(pyridin-4-yl)isonipecotate + sodium tartrate (868-18-8) + potassium tartrate → 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water; ethyl acetate	357 mg (68%)
With sodium hydroxide In tetrahydrofuran; water; ethyl acetate

sodium tartrate (868-18-8) + 1-phenylbenzimidazole-5-carboxylic acid methyl ester (220495-70-5) → 5-(hydroxymethyl)-1-phenylbenzimidazole

Conditions	Yield
With diisobutylaluminium hydride In methanol; dichloromethane

Upstream product

• 50-99-7 D-glucose 
• 133-37-9 DL-tartaric acid 
• 1310-73-2 sodium hydroxide 
• 62-76-0 sodium oxalate 
• 141-52-6 sodium ethanolate 
• 87-69-4 tartaric acid 
• 463-57-0 methanediol 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 52718-49-7 3,7,12-trioxo-5β-cholan-24-oic acid ethyl ester 
• 868-14-4 potassium bitartrate 
• 6381-59-5 rochelle salt 
• 6381-59-5 potassium sodium d-tartrate tetrahydrate 
• 16828-01-6 sodium ammonium (+)-tartrate 
• 147-79-5 rochelle salt 

Downstream Products

• 5892-21-7 calcium mesotartrate*3H₂O 
• 130658-67-2 4-hydroxymethyl-1-(pyridin-4-yl)piperidine 
• 166954-15-0 C-(3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl)-methylamine 
• 725683-58-9 N-(5-chloropyridin-2-yl)-2-[[1-(4-pyridinyl)piperidin-4-yl]methoxy]benzamide 
• 98216-82-1 5-chloro-1,3-dihydroisobenzofuran-1-ol 
• 7440-06-4 platinum 
• 21158-13-4 sodium lead(II) tartrate 
• 19533-76-7 iron(II) tartrate 
• 12010-51-4 bismuth sodium 
• 7664-93-9 sulfuric acid 
• 815-84-9 lead(II) Lg-tartrate 
• 815-82-7 copper(II) tartrate 

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