Welcome to LookChem.com Sign In|Join Free

CAS

  • or

107-35-7

Post Buying Request

107-35-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

107-35-7 Usage

Description

Different sources of media describe the Description of 107-35-7 differently. You can refer to the following data:
1. Taruine is an organic compounds that widely existing in animal tissues. It is a sulfur amino acid, but not being used for protein synthesis. It is rich in the brain, breasts, gallbladder and kidney. It is an essential amino acid in the pre-term and newborn infants of human. It has various kinds of physiological functions including being as a neurotransmitter in the brain, conjugation of bile acids, anti-oxidation, osmoregulation, membrane stabilization, modulation of calcium signaling, regulating the cardiovascular function as well as the development and function of skeletal muscle, the retina, and the central nervous system. It can be manufactured through the ammonolysis of isethionic acid or the reaction of aziridine with sulfurous acid. Because of its highly important physiological role, it can be supplied to energy drinks. It can also be used in cosmetics to maintain skin hydration, and used in some contact lens solution.
2. Taurine is a sulfur-containing amino acid with simple structure in animals. Its chemical name is 2-aminoethanesulfonic acid. Its molecular formula is C2H7NO3S and its molecular weight is 125.15. It is odorless and slightly sour. Its dilute solution is neutral and stable to heat. It combines with cholic acid in human and animal bile and exists in the form of binding; In brain, ovary, heart, liver, milk, pineal gland, pituitary, retina, adrenal gland and other tissues, it exists in free form, with a total amount of 12-18g, but does not participate in protein synthesis. Taurine is a conditionally essential amino acid for human body and plays an important role in the development of fetal and infant nervous system. Taurine can be widely used in medicine, food additives, fluorescent brighteners, organic synthesis and other fields. It can also be used as biochemical reagent, wetting agent, pH buffer and so on.

History

As the conditionally essential amino acid of the human body, it is a kind of β- sulphamic acid. In mammalian tissues, it is a metabolite of methionine and cystine. It was first isolated from ox bile in 1827, hence the name taurine. It commonly exists in the form of free amino acids in various tissues of animals, but not goes into proteins without combination. Taurine is rarely found in plants. Early on, people had considered it a bile acid binding agent of taurocholic combined with cholic acid. However, recent studies have shown that taurine has many important biological functions apart from the above mentioned forming taurocholic acid and participating in the digestion and absorption of lipids.It is important nutrients for normal development and function of cranial nerve to play the role in adjusting a variety of nerve cells of the central nervous system; taurine in retina accounts for 40% to 50% of total free amino acid, which is necessary for maintaining the structure and function of photoreceptor cells; affecting the myocardial contracts dint, regulating calcium metabolism, controlling arrhythmia, lowering blood pressure, etc; maintaining cellular antioxidant activity to protect the tissues from damaging free radicals; decreasing platelet aggregation and so on. As the metabolites containing sulphur amino acids, mammals have different abilities to synthesize taurine: The synthetic ability of rats and dogs is stronger, the synthetic ability of human and primate is lower, while that of kits and human infants is very low. Taurine in the infant mainly comes from the diet, so it is recommended to supplement the taurine in the baby's diet. Foods with a higher content of taurine include conch, clam, mussel, oyster, squid and other shellfish food, which chould be up to 500 ~ 900mg/100g in the table part; the content in fish is comparably different; the content in poultry and offal is also rich; the content in human milk is higher than cow milk; taurine is not found in eggs and vegetable food.

Medicinal effect

Liver-strengthening cholagogue function: The combination of taurine and cholic acid can increase biliary permeability and is related to bile backflow; this product can also reduce cholesterol levels in the liver and reduce the formation of cholesterol calculus. Anti-inflammatory and antipyretic effects: It can lower the body temperature by effects on the central 5-HT system or catecholamine system. Hypotensive effect: After injecting this product, it shows the effects including reducing blood pressure, slowing down heart rate, regulating vascular tension and so on. Cardiac and anti-arrhythmia action: This product can regulate the combination of Ca++ in cardiac myocytes and can reverse the adverse effects of Ca++ on the myocardium. Hypoglycemic effect: This product directly affects the insulin receptor of the liver and muscle cell membrane and has the effect of insulin-like hypoglycemic action. Other effects: loosening up skeletal muscle, reversing myotonia and fighting fatigue after exercise. Local application of this product can reduce the increased pressure in the eyeball caused by prostaglandin; there are still nutritional effects. Clinical use at acute hepatitis, chronic hepatitis, fatty liver, cholecystitis, etc.,as well as use in bronchitis, tonsillitis, ophthalmia and other infectious diseases. This product can be tried for cold, alcohol withdrawal symptoms, arthritis, myotonia, etc.

Preparation

Extract from the mollusk such as fish, shellfish and so on. After reacting to form sodium 2-hydroxyethanesulfonate at 70℃with ethylene oxide and sodium hydrogen sulfite as raw materials, this product can be obtained by further aminolysis and desalination [1]. It can be obtained by reaction between ethylene imine and sulfurous acid [1]. It can be obtained with nitroethylene and sodium bisulfite as raw materials[1]. CH2=CHNO2+NaHSO3→[1] It can be obtained preparing by sulfonation of sodium sulfite and aminolysis in liquid ammonia with sodium sulfite as the raw material [1]. Ethanolamine is used as the raw material to react with hydrochloric acid to form chloroethylamine hydrochloride, which is reacted with sodium sulfite to produce sodium ethylamine sulfonate. This product can be obtained by desalination with dilute sulphuric acid [1]. Use aziridine as the raw material and react with sulfur dioxide and water to obtain this product [1]. Like 6, it can be obtained by using bromoethylamine hydrobromide as the raw material and reacting with sodium sulfite [1]. Use 1, 2-dichloroethane as the raw material and react with sodium sulfite to produce chloroethanesulfonic acid sodium salt. React with ammonia under heating with pressure to form sodium amino ethyl sulfonate. Then it can be prepared by hydrochloric acid-acidification desalination [1]. Like 9, we use hydroxyethanesulphonic acid as the raw material and react with ammonia under heating with pressure to obtain this product [1]. We use 2,2-dimethyl thiazoles as the raw material, hydrogen peroxide or manganese dioxide as the oxidizing agent. This product can be obtained by oxidation under pressure [1], with acetone as by-product at the same time. It can be obtained by using 2-amino alcohol monoester as the raw material and reacting with sodium sulfite [1]. (H2NCH2CH2O)HSO3+Na2SO3→ [1]+Na2SO4 N- vinyl propanamide is used as the raw material to react with sodium bisulfite to produce sodium 2- propane amino ethyl sulfonate. Then this product can be obtained by acidification desalination and hydrolysis.

References

https://en.wikipedia.org/wiki/Taurine https://pubchem.ncbi.nlm.nih.gov/compound/taurine#section=Top

Chemical Properties

Different sources of media describe the Chemical Properties of 107-35-7 differently. You can refer to the following data:
1. Taurine is a naturally occurring amino acid with a bitter taste and sharp flavor. It is a nonessential amino acid by definition because the body can synthesize it from methionine and cysteine.
2. White crystalline powder

Occurrence

Reported found in beef, black beans, chicken, chick peas, clams, cod, fish, lamb, milk, octopus, oysters, pistachios, pork, scallops, shrimp and other natural sources.

Uses

Different sources of media describe the Uses of 107-35-7 differently. You can refer to the following data:
1. Taurine is an organic acid found in animal tissues and is a major constituent of bile. Taurine has many biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization and modulation of calcium signaling.
2. vitamin B1, enzyme cofactor
3. Taurine is an organic acid found in animal tissues and is a major constituent of bile. Taurine has many biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stab ilization and modulation of calcium signaling.

Definition

ChEBI: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral suppleme t in the treatment of disorders such as cystic fibrosis and hypertension.

Biosynthesis

In addition to the intake of taurine directly from the diet, the animal body can also biosynthesis in the liver. The intermediate product of methionine and cysteine metabolism, cysteine, is decarboxylated to taurine by cysteine decarboxylase (CSAD), and then oxidized to taurine. CSAD is considered to be the rate limiting enzyme of taurine biosynthesis in mammals, and compared with other mammals, the activity of human CSAD is lower, which may be due to the low taurine synthesis ability in human body. Taurine can participate in the formation of taurocholic acid and hydroxyethyl sulfonic acid after decomposition in vivo. The amount of taurine required depends on cholic acid binding capacity and muscle content.

General Description

Large white crystals or white powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Taurine is an amino acid found in combination with bile acids [Hawley].

Hazard

Toxic by ingestion.

Health Hazard

ACUTE/CHRONIC HAZARDS: Taurine evolves highly toxic fumes when heated to decomposition, and may cause irritation on contact.

Fire Hazard

Flash point data are not available for Taurine, but Taurine is probably combustible.

Biological Activity

One of the most abundant free amino acids in the brain. A partial agonist at the inhibitory glycine receptor.

Biochem/physiol Actions

Non-selective endogenous agonist at glycine receptors. Conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism.

Pharmacology

Taurine is an organic osmotic regulator. It not only participates in the regulation of cell volume, but also provides the basis for the formation of bile salts. It also plays an important role in the modulation of intracellular free calcium concentration. Although taurine is a special amino acid not included in proteins, taurine is the most abundant amino acid in brain, retina and muscle tissue. Taurine is widely used, such as in the function of central nervous system, cell protection, cardiomyopathy, renal insufficiency, abnormal development of renal function and retinal nerve injury. Almost all eye tissues contain taurine. The quantitative analysis of rat eye tissue extract showed that taurine was the most abundant amino acid in retina, vitreous, lens, cornea, iris and ciliary body. Many studies have found that taurine is an active substance that regulates the normal physiological activities of the body. It has the functions of anti-inflammatory, analgesic, maintaining the osmotic pressure balance of the body, maintaining normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the contractility of the heart, improving the immune capacity of the body, and enhancing the antioxidant capacity of cell membrane Protect a wide range of biological functions such as cardiomyocytes.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

Veterinary Drugs and Treatments

Taurine has proven beneficial in preventing retinal degeneration and the prevention and treatment of taurine-deficiency dilated cardiomyopathy in cats. Although modern commercial feline diets have added taurine, some cats still develop taurine-deficiency associated dilated cardiomyopathy. It may also be of benefit in taurine (±carnitine) deficient cardiomyopathy in American Cocker Spaniels and certain other breeds such as, Golden Retrievers, Labrador Retrievers, Newfoundlands, Dalmations, Portuguese Water Dogs, and English Bulldogs. Preliminary studies have shown evidence that it may be useful as adjunctive treatment for cardiac disease in animals even if taurine deficiency is not present. Because of its low toxicity, some have suggested it be tried for a multitude of conditions in humans and animals; unfortunately, little scientific evidence exists for these uses.

Check Digit Verification of cas no

The CAS Registry Mumber 107-35-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 107-35:
(5*1)+(4*0)+(3*7)+(2*3)+(1*5)=37
37 % 10 = 7
So 107-35-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H-,4,5,6)

107-35-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A12403)  Taurine, 99%   

  • 107-35-7

  • 100g

  • 248.0CNY

  • Detail
  • Alfa Aesar

  • (A12403)  Taurine, 99%   

  • 107-35-7

  • 500g

  • 939.0CNY

  • Detail
  • Alfa Aesar

  • (A12403)  Taurine, 99%   

  • 107-35-7

  • 2500g

  • 3753.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1109)    pharmaceutical secondary standard; traceable to USP

  • 107-35-7

  • PHR1109-1G

  • 732.19CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-10MG

  • 298.35CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-10G

  • 414.18CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-25G

  • 628.29CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-100G

  • 758.16CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-500G

  • 2,538.90CNY

  • Detail
  • Sigma

  • (T0625)  Taurine  ≥99%

  • 107-35-7

  • T0625-1KG

  • 4,416.75CNY

  • Detail
  • Sigma

  • (T8691)  Taurine  meets USP testing specifications, cell culture tested

  • 107-35-7

  • T8691-25G

  • 393.12CNY

  • Detail
  • Sigma

  • (T8691)  Taurine  meets USP testing specifications, cell culture tested

  • 107-35-7

  • T8691-100G

  • 1,095.12CNY

  • Detail

107-35-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name taurine

1.2 Other means of identification

Product number -
Other names tauphon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107-35-7 SDS

107-35-7Synthetic route

cyanomethane-sulfonic acid
753386-85-5

cyanomethane-sulfonic acid

Conditions
ConditionsYield
With hydrogen at 55℃; under 22502.3 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere;99.98%
Cysteamine
60-23-1

Cysteamine

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine In water at 140℃; under 3000.3 Torr; for 0.166667h; Reagent/catalyst; Temperature; Pressure;98.4%
With dihydrogen peroxide; acetic acid
sodium taurinate
7347-25-3

sodium taurinate

Conditions
ConditionsYield
With ethanolamine pH=12.5;95.7%
With sulfuric acid at 80 - 100℃; pH=7.9; Temperature; pH-value;75%
With sulfur dioxide In water pH=5 - 6; Reagent/catalyst;110 g
ammonium 2-nitroethane-1-sulfonate
856367-27-6

ammonium 2-nitroethane-1-sulfonate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen at 20℃; pH=4.2; Concentration; pH-value; Temperature; Reagent/catalyst; Large scale;95.1%
sodium 2-hydroxyethanesulfonate
1562-00-1

sodium 2-hydroxyethanesulfonate

Conditions
ConditionsYield
With C22H24OP(1+)*CH3O3S(1-); ammonia; copper(l) chloride at 160℃; under 73507.4 Torr; for 0.5h; Reagent/catalyst; Temperature; Pressure;95%
Stage #1: sodium 2-hydroxyethanesulfonate pH=12.5;
Stage #2: With ammonia In water at 250℃; under 135014 Torr; for 2h; Autoclave;
91%
With ammonium hydroxide; sodium hydroxide at 250℃; for 2h; Reagent/catalyst; Temperature; Autoclave;78.4%
ammonium taurate

ammonium taurate

Conditions
ConditionsYield
With sulfur dioxide at 20℃; pH=4.2; Concentration; Temperature; pH-value; Large scale;95%
thiazolidine-2-thione
134469-06-0

thiazolidine-2-thione

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide In water at 0 - 5℃;93%
sulfuric acid mono-(2-amino-ethyl ester)
926-39-6

sulfuric acid mono-(2-amino-ethyl ester)

Conditions
ConditionsYield
Stage #1: sulfuric acid mono-(2-amino-ethyl ester) With ammonium sulfite monohydrate at 120℃; for 18h; Autoclave;
Stage #2: With ammonium sulfite monohydrate; sodium hydroxide In water pH=7.2; Temperature;
88.1%
With water; sodium sulfite
sulfuric acid mono-(2-amino-ethyl ester)
926-39-6

sulfuric acid mono-(2-amino-ethyl ester)

ethanolamine
141-43-5

ethanolamine

Conditions
ConditionsYield
With ammonium sulfate; sulfuric acid; ammonium sulfite monohydrate In water at 110℃; for 24h; pH=6.2 - 7.2; Autoclave;85%
2-nitro-1-ethanol
625-48-9

2-nitro-1-ethanol

sodium 2-nitroethanesulfonate
859312-16-6

sodium 2-nitroethanesulfonate

Conditions
ConditionsYield
Stage #1: 2-nitro-1-ethanol With sulfur dioxide; sodium hydroxide for 15h; pH=5.9; Autoclave;
Stage #2: sodium 2-nitroethanesulfonate With hydrogen Autoclave;
81%
ammonium isethionate

ammonium isethionate

Conditions
ConditionsYield
With ammonia pH=6.5; Autoclave;75.7%
monoethanolammonium hydrogensulfate

monoethanolammonium hydrogensulfate

Conditions
ConditionsYield
Stage #1: monoethanolammonium hydrogensulfate With 1-butyl-3-methylimidazolium chloride at 120℃;
Stage #2: With sodium sulfite at 110℃; for 8h; Temperature; Reagent/catalyst;
72%
ethene
74-85-1

ethene

Conditions
ConditionsYield
Stage #1: ethene With sulfur trioxide In acetonitrile under 38000 Torr; for 288h;
Stage #2: With hydrogenchloride In water Heating;
40%
3-sulfopropanoic acid
44826-45-1

3-sulfopropanoic acid

Conditions
ConditionsYield
With sodium azide; chloroform; sulfuric acid at 45℃;
With sodium azide; sulfuric acid for 2.5h; Heating; from 3-14C labeled educt;
cysteic acid
13100-82-8

cysteic acid

Conditions
ConditionsYield
With water at 235 - 240℃;
Decarboxylation;
L-Cysteic acid
498-40-8

L-Cysteic acid

Conditions
ConditionsYield
Decarboxylierung unter anaerober Einwirkung von Leber-Extrakt;
2,2'-dithio-bis[ethylamine]
51-85-4

2,2'-dithio-bis[ethylamine]

Conditions
ConditionsYield
With ammonium iron (II) sulfate; dihydrogen peroxide at 100℃;
With ammonium iron (II) sulfate; dihydrogen peroxide at 100℃;
2-bromoethanesulfonyl chloride
54429-56-0

2-bromoethanesulfonyl chloride

Conditions
ConditionsYield
Hydrolysis.anschl. mit wss. NH3;
2-nitro-ethanesulfonic acid
503863-49-8

2-nitro-ethanesulfonic acid

Conditions
ConditionsYield
With water; nickel Hydrogenation;
With water; nickel Hydrogenation;
Taurocholic acid
81-24-3

Taurocholic acid

N-α-Hydroxypropyl-taurin

N-α-Hydroxypropyl-taurin

A

Tau
107-35-7

Tau

B

propionaldehyde
123-38-6

propionaldehyde

Conditions
ConditionsYield
at 0 - 25℃; Equilibrium constant;
1,2-Thiazetidine 1,1-dioxide
34817-61-3

1,2-Thiazetidine 1,1-dioxide

Conditions
ConditionsYield
In water
With sodium hydroxide; potassium chloride at 30℃; Kinetics;
1-methyl-4-(phenylacetyl)pyridinium cation
124225-44-1

1-methyl-4-(phenylacetyl)pyridinium cation

2-aminoethanesulfonate
56546-93-1

2-aminoethanesulfonate

A

Tau
107-35-7

Tau

B

C14H13NO
114444-46-1

C14H13NO

Conditions
ConditionsYield
In water at 25℃; Rate constant; Equilibrium constant;
C16H36N(1+)*C6H4NO3(1-)*C2H6NO3S(1-)*H(1+)

C16H36N(1+)*C6H4NO3(1-)*C2H6NO3S(1-)*H(1+)

A

Tau
107-35-7

Tau

B

tetra-n-butylammonium p-nitrophenoxide
3002-48-0

tetra-n-butylammonium p-nitrophenoxide

Conditions
ConditionsYield
In 1,4-dioxane; water at 25℃; Equilibrium constant;
(4-hydroxy-1,2-dimethylpyrimidinium-5-yl)methanesulfonate

(4-hydroxy-1,2-dimethylpyrimidinium-5-yl)methanesulfonate

Conditions
ConditionsYield
With sodium hydroxide; sodium azide; sulfuric acid 1.) heating, 2 h .) heating, 2.5 h; Multistep reaction;
2-aminoethylthiosulfonic acid
2937-53-3

2-aminoethylthiosulfonic acid

Conditions
ConditionsYield
With sodium bromate; sodium perchlorate In water at 25℃; Product distribution; Mechanism; various reaction conditions;
With potassium iodate In water at 25℃; Mechanism;
2-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraen-(E)-ylideneamino]-ethanesulfonic acid

2-[(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraen-(E)-ylideneamino]-ethanesulfonic acid

A

Tau
107-35-7

Tau

B

all-trans-Retinal
116-31-4

all-trans-Retinal

Conditions
ConditionsYield
With phosphate buffer Rate constant; also hydrolysis in physiological solution and aq. EtOH;
hypotaurine
300-84-5

hypotaurine

Conditions
ConditionsYield
With chlorine dioxide; sodium perchlorate In water at 25℃; Rate constant; Mechanism;
hypotaurine
300-84-5

hypotaurine

A

Tau
107-35-7

Tau

B

N-chlorotaurine
51036-13-6

N-chlorotaurine

C

N-chlorohypotaurine

N-chlorohypotaurine

Conditions
ConditionsYield
With sodium perchlorate; hypochloric acid In water at 25℃; Rate constant; Mechanism;
1,3-thiazolidine
504-78-9

1,3-thiazolidine

bromine
7726-95-6

bromine

acetic acid
64-19-7

acetic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

N-Benzyloxycarbonyl-taurine sodium salt
136027-16-2

N-Benzyloxycarbonyl-taurine sodium salt

Conditions
ConditionsYield
With sodium hydroxide a) 0 deg C, 30 min, b) 20 deg C, 2 h;100%
With sodium hydroxide In water for 0.5h;100%
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 1h;82%
sodium taurinate
7347-25-3

sodium taurinate

Conditions
ConditionsYield
With sodium hydroxide In water at 60℃; Sonication;100%
With sodium hydrogencarbonate In water at 20℃; for 2h;100%
With sodium hydrogencarbonate In water
With sodium hydroxide In water
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

tetrabutylammonium 2-((tert-butoxycarbonyl)amino)ethane-1-sulfonate

tetrabutylammonium 2-((tert-butoxycarbonyl)amino)ethane-1-sulfonate

Conditions
ConditionsYield
In water; acetone at 20℃;100%
In water; acetone at 20℃;100%
99%
In water; acetone at 20℃; for 12h;95%
In water; acetone at 25℃; for 16h;
4,6,4',6'-tetrachloro-2,2'-(3,6-dioxa-octane-1,8-diyldioxy)-bis-[1,3,5]triazine
36394-85-1

4,6,4',6'-tetrachloro-2,2'-(3,6-dioxa-octane-1,8-diyldioxy)-bis-[1,3,5]triazine

C16H22Cl2N8O10S2(2-)*2Na(1+)

C16H22Cl2N8O10S2(2-)*2Na(1+)

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃;100%
calcium taurine

calcium taurine

Conditions
ConditionsYield
With calcium hydroxide In water at 20℃; for 2h; Time; Reflux;100%
acrylonitrile
107-13-1

acrylonitrile

disodium salt of N-carboxyethyltaurine

disodium salt of N-carboxyethyltaurine

Conditions
ConditionsYield
With sodium hydroxide; nitrogen In water99.8%
acrylonitrile
107-13-1

acrylonitrile

potassium salt of cyanoethyltaurine

potassium salt of cyanoethyltaurine

Conditions
ConditionsYield
With potassium hydroxide In water99.1%
glycolonitrile
107-16-4

glycolonitrile

sodium cyanoethyl taurine

sodium cyanoethyl taurine

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 2h;98.6%
formaldehyd
50-00-0

formaldehyd

nitromethane
75-52-5

nitromethane

N-(2-nitroethyl)taurine

N-(2-nitroethyl)taurine

Conditions
ConditionsYield
In methanol at 70℃; for 4h; Temperature; Solvent; Mannich Aminomethylation; Green chemistry;98.5%
7,8-dihydroxy-chroman-2-one
90560-41-1

7,8-dihydroxy-chroman-2-one

C11H14NO7S(1-)*Na(1+)
1228675-83-9

C11H14NO7S(1-)*Na(1+)

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane at 0 - 20℃;98%
C24H28N2O8

C24H28N2O8

N-taurine
90990-60-6

N-taurine

Conditions
ConditionsYield
With sodium hydroxide at -10 - 0℃; for 8h;97.6%
copper(I) oxide

copper(I) oxide

1,10-phenanthroline-2,9-dicarboxaldehyde
57709-62-3

1,10-phenanthroline-2,9-dicarboxaldehyde

2Na(1+)*[Cu2(C12H6N2(CHNC2H4SO3)2)2](2-)=Na2[Cu2(C12H6N2(CHNC2H4SO3)2)2]

2Na(1+)*[Cu2(C12H6N2(CHNC2H4SO3)2)2](2-)=Na2[Cu2(C12H6N2(CHNC2H4SO3)2)2]

Conditions
ConditionsYield
With NaHCO3 In water (Ar or N2); a flask charged with 1,10-phenanthroline-2,9-dicarboxaldehyde, sulfanilic acid, Cu2O, NaHCO3, sealed, purified of O2, H2O added, sealed, stirred at room temp.; evapd. (vac.);97%
C18H32N2O8

C18H32N2O8

2-((S)-2,5-Bis-tert-butoxycarbonylamino-pentanoylamino)-ethanesulfonic acid

2-((S)-2,5-Bis-tert-butoxycarbonylamino-pentanoylamino)-ethanesulfonic acid

Conditions
ConditionsYield
With sodium hydroxide at 0 - 10℃; for 2h;96.9%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2–((tert-butoxycarbonyl)amino)ethyl-1-sulfonic acid

2–((tert-butoxycarbonyl)amino)ethyl-1-sulfonic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; methanol at 10℃; for 24h; Temperature; Cooling with ice;96%
With sodium hydroxide; water In tetrahydrofuran for 15h; Ambient temperature; Yield given;
With sodium hydroxide In tetrahydrofuran; water at 20℃;
With dmap; triethylamine In dichloromethane at 0℃;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

copper(I) oxide

copper(I) oxide

methanol
67-56-1

methanol

Na(1+)*Cu(C5H4NCHNCH2CH2SO3)2(1-)*2CH3OH = Na(Cu(C5H4NCHNCH2CH2SO3)2)*2CH3OH

Na(1+)*Cu(C5H4NCHNCH2CH2SO3)2(1-)*2CH3OH = Na(Cu(C5H4NCHNCH2CH2SO3)2)*2CH3OH

Conditions
ConditionsYield
With sodium hydrogencarbonate; tert-butyl alcohol In water-d2 (Ar or N2); pyridine-2-carboxaldehyde, taurine, Cu2O, NaHCO3 added to flask; sealed; mag. stirring-bar added; water added; flask sealed; stirredfor 8 h at 22°C; volatiles removed under dynamic vac.; methanol and tert-butanol added; pptd.; crystals allowed to settle; supernatant removed with cannula filter; dried under dynamic vac. for 4 h; elem. anal.;96%
lithium 2-aminoethanesulfonate
117998-05-7

lithium 2-aminoethanesulfonate

Conditions
ConditionsYield
Stage #1: Tau With lithium hydroxide monohydrate In water at 20℃;
Stage #2: In toluene at 100℃; for 12h;
96%
C26H28N2O10

C26H28N2O10

C23H25N3O10S

C23H25N3O10S

Conditions
ConditionsYield
With potassium hydroxide In water at -10 - 0℃; for 6h;96%
(rac)-gossypol
303-45-7

(rac)-gossypol

megosin

megosin

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 3h; Heating;95.8%
cholic acid
81-25-4

cholic acid

sodium taurocholate
145-42-6

sodium taurocholate

Conditions
ConditionsYield
Stage #1: Tau; cholic acid With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine In N,N-dimethyl-formamide at 90℃; for 2h;
Stage #2: With sodium hydroxide In methanol at 20℃; for 1h;
95%
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol at 20 - 80℃;88%
Deoxycholic acid
83-44-3

Deoxycholic acid

sodium taurodeoxycholate
1180-95-6

sodium taurodeoxycholate

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol at 20 - 80℃;95%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

tauroursodeoxycholic acid sodium salt
35807-85-3

tauroursodeoxycholic acid sodium salt

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; acetonitrile; tert-butyl alcohol at 20 - 80℃;95%
(±)-gossypol acetic acid
5453-04-3, 866541-93-7, 1189561-66-7

(±)-gossypol acetic acid

megosin

megosin

Conditions
ConditionsYield
Stage #1: Tau With sodium hydroxide In ethanol for 1h; Reflux;
Stage #2: (±)-gossypol acetic acid In ethanol for 5h; Reflux;
94%
Stage #1: Tau With sodium hydroxide In ethanol for 1h; Reflux;
Stage #2: (±)-gossypol acetic acid In ethanol for 5h; Reflux;
94%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

sodium taurochenodeoxycholate
6009-98-9

sodium taurochenodeoxycholate

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; acetonitrile; tert-butyl alcohol at 20 - 80℃;93%

107-35-7Relevant articles and documents

Reactivity and the mechanisms of reactions of β-sultams with nucleophiles

Wood, J. Matthew,Hinchliffe, Paul S.,Laws, Andrew P.,Page, Michael I.

, p. 938 - 946 (2002)

Ethane-1,2-sultam has a pKa of 12.12±0.06 at 30 °C and its rate of alkaline hydrolysis shows a pH-dependence reflecting this so that the observed pseudo first-order rate constant at phs above the pKa are pH independent. There is no evidence of neighbouring group participation in the hydrolysis of either N-α-carboxybenzylethane-1,2-sultam or N-(hydroxyaminocarbonylmethyl)-2-benzylethane-1,2-sultam. Oxyanions, but not amines or thiols, react with N-benzoylethane-1,2-sultam in water by a nucleophilic ring opening reaction confirmed by product analysis and kinetic solvent isotope effects. A Bronsted plot for this reaction has two distinct correlations with βnuc = 0.52 and 0.65 for weak and strong bases, respectively, although a statistically corrected plot may indicate a single correlation.

-

Goldberg

, p. 4 (1943)

-

Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate

Catucci, Gianluca,Cheropkina, Hanna,Fenoglio, Ivana,Gilardi, Gianfranco,Marucco, Arianna,Sadeghi, Sheila J.

, (2021)

Out of the five isoforms of human flavin-containing monooxygenase (hFMO), FMO1 and FMO3 are the most relevant to Phase I drug metabolism. They are involved in the oxygenation of xenobiotics including drugs and pesticides using NADPH and FAD as cofactors. Majority of the characterization of these enzymes has involved hFMO3, where intermediates of its catalytic cycle have been described. On the other hand, research efforts have so far failed in capturing the same key intermediate that is responsible for the monooxygenation activity of hFMO1. In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2. The measured half-life of this flavin intermediate revealed it to be stable and not fully re-oxidized even after 30 min at 15 °C in the absence of substrate, the highest stability ever observed for a human FMO. In addition, the uncoupling reactions of hFMO1 show that this enzyme is 2O2 with no observable superoxide as confirmed by EPR spin trapping experiments. This behaviour is different from hFMO3, that is shown to form both H2O2 and superoxide anion radical as a result of ~50% uncoupling. These data are consistent with the higher stability of the hFMO1 intermediate in comparison to hFMO3. Taken together, these data demonstrate the different behaviours of these two closely related enzymes with consequences for drug metabolism as well as possible toxicity due to reactive oxygen species.

Oxyhalogen-sulfur chemistry: Non-linear oxidation of 2-aminoethanethiolsulfuric acid (AETSA) by bromate in acidic medium

Darkwa, James,Mundoma, Claudius,Simoyi, Reuben H.

, p. 4407 - 4413 (1996)

The reaction between bromate and 2-aminoethanethiolsulfuric acid, H2NCH2CH2S-SO3H (AETSA), has been studied in high acid environments. The stoichiometry in excess AETSA is BrO3- + H2NCH2CH2S-SO3H + H2O → H2NCH2CH2SO3H + SO42- + 2H+ + Br- . In excess BrO3- the stoichiometry is: 7BrO3- + 5H2NCH2CH2S-SO3H → 5Br(H)NCH2CH2SO3H + 5SO42- + Br2 + 3H+ + H2O. The reaction displays clock reaction characteristics in which there is initial quiescence followed by a sudden and rapid formation of Br2(aq). The oxidation proceeds by successive addition of oxygen on the inner sulfur atom followed by cleavage of the S-S bond to form taurine and SO42-. The Br2(aq) and the HOBr in solution oxidize the taurine to form a mixture of monobromotaurine and dibromotaurine. Computer simulations of a proposed 13-step reaction scheme produced a reasonable fit to the experimental data.

Bioactive metabolites from the Caribbean sponge Aka coralliphagum

Grube, Achim,Assmann, Michael,Lichte, Ellen,Sasse, Florenz,Pawlik, Joseph R.,Koeck, Matthias

, p. 504 - 509 (2007)

The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.

Kermack,Slater

, p. 1065 (1927)

Trofosides A and B and other cytostatic steroid-derived compounds from the far east starfish Trofodiscus ueber

Levina,Kalinovsky,Andriyashchenko,Menzorova,Dmitrenok

, p. 334 - 340 (2007)

Three new polar steroids identified as trofoside A, 20R,24S)-24-O-(3-O- methyl-β-D-xylopyranosyl)-3β,6α,8,15β,24-pentahydroxy- 5α-cholestane, its 22(23)-dehydro derivative (trofoside B), and 15-sulfooxy-(20R,24S)-5α-cholestane-3β,6β,8,15α, 24-pentaol sodium salt, were isolated fromTrofodiscus ueber starfish extracts collected in the Sea of Ohotsk. Two known compounds, trofoside A aglycone, (20R,24S)-3β,6α,8,15β,24-pentahydroxy-5α- cholestane, and triseramide, (20R,24R,25S,22E)-24-methyl-3β6α,8, 15β-tetrahydroxy-5α-cholest-22-en-27-oic acid (2-sulfoethyl)amide sodium salt, were also found. The structures of the isolated polyoxysteroids were established from their spectra. Minimal concentrations causing degradation of unfertilized egg-cells of the sea-urchin Strongylocentrotus intermedius(C min) and terminating the cell division at the stage of the first division (C min embr.), as well as the concentrations causing 50% immobilization of sperm cells (OC50) and inhibiting their ability to fertilize egg-cells by 50% (IC50) were determined for the isolated compounds. Of three compounds highly toxic in embryos and sea-urchin sperm cells, the polyol with a sulfo group in the steroid core was the most active; two glycosides with monosaccharide chains located at C3 and C24 atoms were less toxic. Note that all the compounds with the spermiotoxic activities differently affected the embryo development. The positions of monosaccharide residues in the core considerably influence the compound activity. For example, both mono-and double chained glycosides with the monosaccharide fragment at C3 and fragments at C3 and C4 atoms are active against sea-urchin sperm cells and embryos, whereas the C24 glycosylated trofoside A does not affect embryos and displays a poor spermiotoxicity. Nauka/Interperiodica 2007.

Purification and characterization of the first archaeal glutamate decarboxylase from Pyrococcus horikoshii

Kim, Han-Woo,Kashima, Yasuhiro,Ishikawa, Kazuhiko,Yamano, Naoko

, p. 224 - 227 (2009)

Glutamate decarboxylase (GAD) from the archaeon Pyrococcus horikoshii was successfully expressed and purified, with the aim of developing a hyperthermostable GAD for industrial applications. Its biochemical properties were different from those reported for other GADs. The enzyme had broad substrate specificity, and its optimum pH and temperature were pH 8.0 and >97°C.

PROCESS SULFONATION OF AMINOETHYLENE SULFONIC ESTER TO PRODUCE TAURINE

-

Paragraph 0030-0031, (2021/06/04)

A process comprises continuously adding a first stream and a second stream to a sulfonation vessel, wherein the first stream comprises aminoethanol sulfate ester (AES) and the second stream comprises an aqueous solution of sodium sulfite (Na2SO3). The process comprises continuously mixing the AES and the aqueous solution of Na2SO3 in the sulfonation vessel, thus producing a mixture. The process comprises continuously subjecting the mixture to heat in the presence of an inert gas, thus converting the AES to the taurine via sulfonation. In an aspect, the AES has a residence time of no more than four hours in the sulfonation vessel. In an aspect the heating step is conducted at a temperature of at least 115° C and a pressure of at least 200 psi.

Taurine synthesis method (by machine translation)

-

Paragraph 0036; 0039-0041; 0044-0045; 0048-0049; 0052, (2020/07/15)

The invention provides a taurine synthesis method, and solves the problems of by-product accumulation, high temperature and high pressure in ammonia decomposition reaction, strong strong acid and strong base in acidification and the like in an addition reaction in a traditional taurine synthesis process. The method comprises the following steps: 1) carrying out cyclization reaction of sulfur solution and ethylene contact to obtain a solution of sulfur dissolved in carbon disulfide; 2) carrying out an addition reaction with ammonia or liquid ammonia contact to obtain an amino thiol; 3) carrying out an oxidation reaction in the presence of a catalyst to obtain the crude taurine. (by machine translation)

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 107-35-7