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120-73-0 Usage

Chemical Properties

very slightly yellow to cream crystalline powder

Uses

Different sources of media describe the Uses of 120-73-0 differently. You can refer to the following data:
1. Organic synthesis, metabolism, and biochemi- cal research. (2) One of a number of basic compounds found in living matter and having a purine-type molecular structure.
2. Purine can be used human immunogenic epitopes of H,K, and E human endogenous retroviruses.
3. Purine can undergo direct C-H functionalization in the presence of palladium catalyst to form various biologically important products.

Definition

Different sources of media describe the Definition of 120-73-0 differently. You can refer to the following data:
1. A simple nitrogenous organic molecule with a double ring structure. Members of the purine group include adenine and guanine, which are constituents of the nucleic acids, and certain plant alkaloids, such as caffeine and theobromine.
2. purine: An organic nitrogenous base(see formula), sparingly soluble inwater, that gives rise to a group ofbiologically important derivatives,notably adenine and guanine,which occur in nucleotides and nucleicacids (DNA and RNA).
3. ChEBI: The 9H-tautomer of purine.

General Description

Purine is a heterocyclic organic compound constituting a pyrimidine ring fused to an imidazole ring.

Purification Methods

It crystallises from toluene or EtOH, and sublimes at 100-150o/0.1mm or 160o/10-4mm. The picrate has m 207-209o after crystallisation from 20volumes of H2O. [Beilstein 26 H 354, 26 III/IV 1736.]

Check Digit Verification of cas no

The CAS Registry Mumber 120-73-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 120-73:
(5*1)+(4*2)+(3*0)+(2*7)+(1*3)=30
30 % 10 = 0
So 120-73-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-4H

120-73-0 Well-known Company Product Price

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  • Aldrich

  • (P55805)  Purine  98%

  • 120-73-0

  • P55805-1G

  • 2,292.03CNY

  • Detail

120-73-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 9H-purine

1.2 Other means of identification

Product number -
Other names 9H-PURINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120-73-0 SDS

120-73-0Synthetic route

6-mercaptopurine
50-44-2

6-mercaptopurine

A

purine
120-73-0

purine

B

hypoxanthine
68-94-0

hypoxanthine

C

purine-6-sulfonic acid
25023-39-6

purine-6-sulfonic acid

Conditions
ConditionsYield
With oxygen In tert-butyl alcohol for 0.166667h; Irradiation; other solvent: AcOH;A 20%
B 58%
C n/a
With oxygen In tert-butyl alcohol for 0.166667h; Product distribution; Quantum yield; Irradiation; other solvents: acetic acid, H2O, D2O; other objects of study: effects of adding H2O, NaN3, thiourea, hydroquinone;A 20%
B 58%
C n/a
With oxygen In acetic acid for 0.166667h; Irradiation; other solvent: t-BuOH;A 36%
B 17%
C n/a
1-aminopurinium mesitylenesulfonates

1-aminopurinium mesitylenesulfonates

purine
120-73-0

purine

Conditions
ConditionsYield
With ammonia In methanol at 50℃; for 5h; Product distribution; Mechanism; ANRORC mechanism determined by reaction with 15N labelled ammonia; var. temp. and time;40%
4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

carbon dioxide
124-38-9

carbon dioxide

purine
120-73-0

purine

Conditions
ConditionsYield
With phenylsilane; 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene at 70℃; for 24h; Reagent/catalyst;28%
With N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; phenylsilane In tetrahydrofuran at 70℃; under 750.075 - 2250.23 Torr; for 24h; Schlenk technique; Inert atmosphere; Glovebox;
Conditions
ConditionsYield
In methanol at 100℃; for 17h;A 10%
B 15%
C 25%
tetrahydrofuran
109-99-9

tetrahydrofuran

1,3,5-Triazine
290-87-9

1,3,5-Triazine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

purine
120-73-0

purine

1,4-dioxane
123-91-1

1,4-dioxane

1,3,5-Triazine
290-87-9

1,3,5-Triazine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

purine
120-73-0

purine

Conditions
ConditionsYield
unter Stickstoff;
1,3,5-Triazine
290-87-9

1,3,5-Triazine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

purine
120-73-0

purine

Conditions
ConditionsYield
unter Stickstoff;
1,3,5-Triazine
290-87-9

1,3,5-Triazine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

benzene
71-43-2

benzene

purine
120-73-0

purine

1,3,5-Triazine
290-87-9

1,3,5-Triazine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

purine
120-73-0

purine

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

formic acid
64-18-6

formic acid

purine
120-73-0

purine

Conditions
ConditionsYield
at 210℃;
at 210℃; und Erwaermen des Reaktionsprodukts mit CaCO3 in Aethanol;
at 210℃;
2,6,8-trichloro-7H-purine
2562-52-9

2,6,8-trichloro-7H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
With palladium on activated charcoal; sodium acetate Hydrogenation;
6H-purine-6-thione
50-44-2

6H-purine-6-thione

purine
120-73-0

purine

Conditions
ConditionsYield
With ammonium hydroxide; nickel
1,2,3,6-Tetrahydro-2,6-dithio-7H-purine
5437-25-2

1,2,3,6-Tetrahydro-2,6-dithio-7H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
With ammonium hydroxide; nickel
Conditions
ConditionsYield
With ammonia at 200℃; under 220652 Torr;
at 160℃; for 48h;
6-chloro-7H-purine
87-42-3

6-chloro-7H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
With palladium on activated charcoal; water Hydrogenation;
Multi-step reaction with 2 steps
1: ethanol
2: Raney nickel; aqueous NH3
View Scheme
7H-purine-6-carboxylic acid
2365-43-7

7H-purine-6-carboxylic acid

purine
120-73-0

purine

Conditions
ConditionsYield
at 300℃;
4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

1-tosyl-3,4,4-trimethyl-Δ2-imidazolinium iodide
71254-91-6

1-tosyl-3,4,4-trimethyl-Δ2-imidazolinium iodide

purine
120-73-0

purine

Conditions
ConditionsYield
In acetonitrile at 50 - 60℃; for 1h; Yield given;
(2R,3S,5R)-2-(hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3-ol
4546-68-3

(2R,3S,5R)-2-(hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3-ol

purine
120-73-0

purine

Conditions
ConditionsYield
In hydrogenchloride; water at 50.1℃; Kinetics; Mechanism;
4-amino-5-formamidopyrimidine
16008-45-0

4-amino-5-formamidopyrimidine

A

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

B

purine
120-73-0

purine

Conditions
ConditionsYield
With sodium hydroxide at 70.1℃; Rate constant; different hydroxide ion concentrations;
4-amino-5-formamidopyrimidine
16008-45-0

4-amino-5-formamidopyrimidine

A

4,5-pyrimidinediamine
13754-19-3

4,5-pyrimidinediamine

B

formic acid
64-18-6

formic acid

C

purine
120-73-0

purine

Conditions
ConditionsYield
With perchloric acid at 90.1℃; Rate constant; Mechanism; Thermodynamic data; prod. yield/prod. distrib.; other temperatures, other reagent, ΔS(excit.), pH influence, phosphate buffer influence;
1-C-(purin-N9-yl)-1,2,3-dideoxy-β-D-erythro-furanose
126502-08-7

1-C-(purin-N9-yl)-1,2,3-dideoxy-β-D-erythro-furanose

A

purine
120-73-0

purine

B

2,3-Didesoxy-β-D-glycero-pentofuranose
122999-44-4

2,3-Didesoxy-β-D-glycero-pentofuranose

Conditions
ConditionsYield
With hydrogenchloride at 22℃; rate of hydrolysis relative to dideoxyadenosine;
1-Ethyl-1H,5H-imidazo[2,1-b]purin-4-one; compound with 7H-purine

1-Ethyl-1H,5H-imidazo[2,1-b]purin-4-one; compound with 7H-purine

A

purine
120-73-0

purine

B

N2,3-Etheno-9-ethylguanine
137063-89-9

N2,3-Etheno-9-ethylguanine

Conditions
ConditionsYield
In dichloromethane; water at 25.1℃; Equilibrium constant;
1-Ethyl-4-methoxy-1H-imidazo[2,1-b]purine; compound with 7H-purine

1-Ethyl-4-methoxy-1H-imidazo[2,1-b]purine; compound with 7H-purine

A

purine
120-73-0

purine

B

N2,3-Etheno-9-ethyl-O6-methylguanine
137063-88-8

N2,3-Etheno-9-ethyl-O6-methylguanine

Conditions
ConditionsYield
In dichloromethane; water at 25.1℃; Equilibrium constant;
1-Ethyl-5-methyl-1H,5H-imidazo[2,1-b]purin-4-one; compound with 7H-purine

1-Ethyl-5-methyl-1H,5H-imidazo[2,1-b]purin-4-one; compound with 7H-purine

A

purine
120-73-0

purine

B

N2,3-Etheno-9-ethyl-1-methylguanine
137063-87-7

N2,3-Etheno-9-ethyl-1-methylguanine

Conditions
ConditionsYield
In dichloromethane; water at 25.1℃; Equilibrium constant;
9-(1-methoxyethyl)purine
95103-63-2

9-(1-methoxyethyl)purine

purine
120-73-0

purine

Conditions
ConditionsYield
In hydrogenchloride; water at 40.1℃; Kinetics; Mechanism;
9-(1-ethoxyethyl)-9H-purine
78105-09-6

9-(1-ethoxyethyl)-9H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
In hydrogenchloride; water at 40.1℃; Kinetics; Mechanism;
9-(1-Isopropoxy-ethyl)-9H-purine
95103-62-1

9-(1-Isopropoxy-ethyl)-9H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
In hydrogenchloride; water at 40.1℃; Kinetics; Mechanism;
9-[1-(2-Chloro-ethoxy)-ethyl]-9H-purine
95103-65-4

9-[1-(2-Chloro-ethoxy)-ethyl]-9H-purine

purine
120-73-0

purine

Conditions
ConditionsYield
In hydrogenchloride; water at 40.1℃; Kinetics; Mechanism;
6-mercaptopurine
50-44-2

6-mercaptopurine

A

purine
120-73-0

purine

B

hypoxanthine
68-94-0

hypoxanthine

Conditions
ConditionsYield
With oxygen; methylene blue In tert-butyl alcohol for 0.433333h; Product distribution; Irradiation; other sensitizers: rhodamine, bengal red; other times of irradiation: 210 min, 52 min; other conditions: thermal reaction with 9,10-diphenylanthracene endo-peroxide;
purine
120-73-0

purine

3,4,6-tri-O-benzyl-2-nitro-D-galactal
211621-55-5

3,4,6-tri-O-benzyl-2-nitro-D-galactal

9-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-galactopyranosyl)purine
305839-89-8

9-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-β-D-galactopyranosyl)purine

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; Michael addition; Glycosylation;91%
purine
120-73-0

purine

2-chloro-1-(6H-indolo[2,3-b]quinoxalin-6-yl)ethan-1-one

2-chloro-1-(6H-indolo[2,3-b]quinoxalin-6-yl)ethan-1-one

1-(6H-indolo[2,3-b]quinoxalin-6-yl)-2-(7H-purin-7-yl)ethan-1-one

1-(6H-indolo[2,3-b]quinoxalin-6-yl)-2-(7H-purin-7-yl)ethan-1-one

Conditions
ConditionsYield
In toluene for 1.25h; Reflux;91%
purine
120-73-0

purine

rac-ethyl 5-((tert-butoxycarbonyl)oxy)cyclopent-1-ene-1-carboxylate

rac-ethyl 5-((tert-butoxycarbonyl)oxy)cyclopent-1-ene-1-carboxylate

(R)-ethyl 5-(9H-purin-9-yl)cyclopent-1-ene-1-carboxylate

(R)-ethyl 5-(9H-purin-9-yl)cyclopent-1-ene-1-carboxylate

Conditions
ConditionsYield
Stage #1: purine With tris-(dibenzylideneacetone)dipalladium(0); (S,S)-[2-(4'-isopropyloxazolin-2'-yl)ferrocenyl]diphenylphosphine; α-naphthol; potassium carbonate In toluene at 20℃; for 0.5h; Inert atmosphere;
Stage #2: rac-ethyl 5-((tert-butoxycarbonyl)oxy)cyclopent-1-ene-1-carboxylate In toluene at 0℃; for 72h; Reagent/catalyst; Temperature;
82%
5-[1-(chloromethoxy)ethyl]-6-nitro-1,3-benzodioxole
911377-03-2

5-[1-(chloromethoxy)ethyl]-6-nitro-1,3-benzodioxole

purine
120-73-0

purine

7-{[1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]methyl}-7H-purine

7-{[1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]methyl}-7H-purine

Conditions
ConditionsYield
Stage #1: purine With 18-crown-6 ether; potassium hydride In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 5-[1-(chloromethoxy)ethyl]-6-nitro-1,3-benzodioxole In N,N-dimethyl-formamide at -78 - 0℃; for 12h; Further stages.;
78%
bis(η3-allyl-μ-chloropalladium(II))

bis(η3-allyl-μ-chloropalladium(II))

purine
120-73-0

purine

μ-(purine)-bis[η3-allylchloropalladium(II)]
96226-56-1

μ-(purine)-bis[η3-allylchloropalladium(II)]

Conditions
ConditionsYield
In methanol soln. stirred for 2h; concd., addn. of ether, pptn., washed (ether), dried, elem. anal.;78%
tert-butylethylene
558-37-2

tert-butylethylene

purine
120-73-0

purine

A

8-(3,3-dimethyl-butyl)-7H-purine

8-(3,3-dimethyl-butyl)-7H-purine

B

6,8-bis-(3,3-dimethyl-butyl)-7H-purine

6,8-bis-(3,3-dimethyl-butyl)-7H-purine

Conditions
ConditionsYield
With lutidinium chloride; tricyclohexylphosphine; [RhCl(coe)2]2 In tetrahydrofuran at 150℃; for 4.5h;A 76%
B 17%
2-(isopropylsulfonyl)-1-phenylpropan-1-one

2-(isopropylsulfonyl)-1-phenylpropan-1-one

purine
120-73-0

purine

2-isopropyl-7H-purine

2-isopropyl-7H-purine

Conditions
ConditionsYield
With trifluoroacetic acid In acetone at 80℃; Minisci Aromatic Substitution; Inert atmosphere; Schlenk technique; UV-irradiation;72%
purine
120-73-0

purine

Cyclohexanecarboxylic acid
98-89-5

Cyclohexanecarboxylic acid

6-cyclohexylpurine

6-cyclohexylpurine

Conditions
ConditionsYield
With hydrogenchloride; cerium(III) chloride heptahydrate; tetrabutyl-ammonium chloride In 2,2,2-trifluoroethanol; water for 17h; Schlenk technique; Inert atmosphere; Electrochemical reaction; Irradiation;70%
purine
120-73-0

purine

manganese(II) oxalate dihydrate
89087-78-5, 136029-14-6

manganese(II) oxalate dihydrate

[Mn(μ-oxalato)(H2O)(7H-purine-κN(9))](n)
880772-25-8

[Mn(μ-oxalato)(H2O)(7H-purine-κN(9))](n)

Conditions
ConditionsYield
With K2C2O4*H2O In water a soln. of pyrine added dropwise to a soln. of Mn and K salts; filtered, crystd. for days; elem. anal.;65%
purine
120-73-0

purine

Langlois reagent
2926-29-6

Langlois reagent

8-(trifluoromethyl)-9H-purine
2268-12-4

8-(trifluoromethyl)-9H-purine

Conditions
ConditionsYield
With dimethylglyoxal In water at 20℃; for 20h; Irradiation; Inert atmosphere;65%
xanthene
92-83-1

xanthene

purine
120-73-0

purine

7-(9H-xanthen-9-yl)-7H-purine

7-(9H-xanthen-9-yl)-7H-purine

Conditions
ConditionsYield
With methanesulfonic acid; tetrabutylammonium tetrafluoroborate In acetonitrile at 20℃; for 2h; Electrochemical reaction;58%
cyclopent-2-enone
930-30-3

cyclopent-2-enone

purine
120-73-0

purine

C10H10N4O
1417720-85-4

C10H10N4O

Conditions
ConditionsYield
With cerium(III) chloride heptahydrate; silica gel; sodium iodide In neat (no solvent) at 20℃; for 18h; Michael Addition;52%
cyclohexenone
930-68-7

cyclohexenone

purine
120-73-0

purine

A

C11H12N4O
1043963-39-8

C11H12N4O

B

C11H12N4O
1043963-38-7

C11H12N4O

Conditions
ConditionsYield
In water at 60℃; under 4500450 Torr; for 20h; Aza-Michael reaction;A 36%
B 51%
(E)-1,2,3-tri-O-acetyl-5,6,7-trideoxy-7-C-phthalimido-D-ribohept-5-enofuranose
1204745-03-8

(E)-1,2,3-tri-O-acetyl-5,6,7-trideoxy-7-C-phthalimido-D-ribohept-5-enofuranose

purine
120-73-0

purine

9-[(5E)-2,3-di-O-acetyl-5,6,7-trideoxy-7-phthalimido-β-D-ribo-hept-5-enofuranosyl]purine
1312944-43-6

9-[(5E)-2,3-di-O-acetyl-5,6,7-trideoxy-7-phthalimido-β-D-ribo-hept-5-enofuranosyl]purine

Conditions
ConditionsYield
Stage #1: purine With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile at 60℃; for 1.5h; Inert atmosphere;
Stage #2: (E)-1,2,3-tri-O-acetyl-5,6,7-trideoxy-7-C-phthalimido-D-ribohept-5-enofuranose With tin(IV) chloride In acetonitrile at 60℃; for 1.5h; Vorbruggen nucleosidation reaction; Inert atmosphere;
51%
purine
120-73-0

purine

1,2,3,5-tetraacetylribose
13035-61-5

1,2,3,5-tetraacetylribose

2',3',5'-tri-O-acetylnebularine
15981-63-2

2',3',5'-tri-O-acetylnebularine

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride In acetonitrile at 60℃; for 3h; Vorbruggen nucleosidation reaction; Inert atmosphere;51%
N-anthracenoyl-3,3-dimethyl-5-acetoxy-1,2-isoxazolidine
1416969-42-0

N-anthracenoyl-3,3-dimethyl-5-acetoxy-1,2-isoxazolidine

purine
120-73-0

purine

A

C25H21N5O2

C25H21N5O2

B

C25H21N5O2

C25H21N5O2

Conditions
ConditionsYield
Stage #1: purine With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane for 1h; Vorbrueggen Nucleoside Synthesis; Inert atmosphere; Reflux;
Stage #2: N-anthracenoyl-3,3-dimethyl-5-acetoxy-1,2-isoxazolidine With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; Vorbrueggen Nucleoside Synthesis; Inert atmosphere; Reflux;
A 51%
B 45%
purine
120-73-0

purine

mesitylenesulfonylhydroxylamine
36016-40-7

mesitylenesulfonylhydroxylamine

1-aminopurinium mesitylenesulfonates

1-aminopurinium mesitylenesulfonates

Conditions
ConditionsYield
In methanol; dichloromethane for 4h; Product distribution; Ambient temperature; reactions of derivatives;45%
In methanol; dichloromethane for 4h; Ambient temperature;45%
purine
120-73-0

purine

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

A

7-methylpurine
18346-04-8

7-methylpurine

B

9-methylpurine
20427-22-9

9-methylpurine

Conditions
ConditionsYield
In toluene for 6h; Heating;A 45%
B 30%
purine
120-73-0

purine

2',3'-Dideoxyuridine
5983-09-5

2',3'-Dideoxyuridine

1-C-(purin-N9-yl)-1,2,3-dideoxy-β-D-erythro-furanose
126502-08-7

1-C-(purin-N9-yl)-1,2,3-dideoxy-β-D-erythro-furanose

Conditions
ConditionsYield
at 50℃; for 4h; Escherichia coli JA-300 cells, pH = 6.5;43%
purine
120-73-0

purine

methyl iodide
74-88-4

methyl iodide

A

7-methylpurine
18346-04-8

7-methylpurine

B

9-methylpurine
20427-22-9

9-methylpurine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide 1.) 0 deg C, 20 min, 2.) 2 h;A 15%
B 40%
Dimethyl oxalate
553-90-2

Dimethyl oxalate

purine
120-73-0

purine

9-methylpurine
20427-22-9

9-methylpurine

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide for 1h; Heating;37%
With potassium tert-butylate In N,N-dimethyl-formamide Heating;37%
cis-[Ru(2,2':6',2''-terpyridine)(2-(2'-hydroxyphenyl)benzoxazole)(H2O)](PF6)2*3H2O

cis-[Ru(2,2':6',2''-terpyridine)(2-(2'-hydroxyphenyl)benzoxazole)(H2O)](PF6)2*3H2O

purine
120-73-0

purine

cis-[Ru(2,2':6',2''-terpyridine)(2-(2'-hydroxyphenyl)benzoxazole)(purine)](PF6)*2H2O

cis-[Ru(2,2':6',2''-terpyridine)(2-(2'-hydroxyphenyl)benzoxazole)(purine)](PF6)*2H2O

Conditions
ConditionsYield
In water for 42h;37%
10-(3-bromo-propoxy)-(20S)-7-ethyl-camptothecin
1233334-18-3

10-(3-bromo-propoxy)-(20S)-7-ethyl-camptothecin

purine
120-73-0

purine

10-(3-purinyl-propoxy)-(20S)-7-ethyl-camptothecin
1233334-32-1

10-(3-purinyl-propoxy)-(20S)-7-ethyl-camptothecin

Conditions
ConditionsYield
In dimethyl sulfoxide at 50℃; for 72h;32%
N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methylbenzamide
1570134-59-6

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methylbenzamide

purine
120-73-0

purine

A

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methyl-6-(9H-purin-9-yl)benzamide

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methyl-6-(9H-purin-9-yl)benzamide

B

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methyl-6-(7H-purin-7-yl)benzamide

N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2-methyl-6-(7H-purin-7-yl)benzamide

Conditions
ConditionsYield
With copper diacetate; sodium carbonate In dimethyl sulfoxide at 90℃; for 5h; Sealed tube;A 32%
B 24%
2,2,4,4-tetramethyl-3-methylenecyclobutan-1-one
20019-11-8

2,2,4,4-tetramethyl-3-methylenecyclobutan-1-one

purine
120-73-0

purine

9-(3,3,5,5-Tetramethyl-4-methylene-tetrahydro-furan-2-yl)-9H-purine
125092-17-3

9-(3,3,5,5-Tetramethyl-4-methylene-tetrahydro-furan-2-yl)-9H-purine

Conditions
ConditionsYield
In acetonitrile for 78h; Irradiation;31%
(2-benzoyloxyethyl)oxymethyl chloride
58305-05-8

(2-benzoyloxyethyl)oxymethyl chloride

purine
120-73-0

purine

9-(2-benzoyloxyethoxymethyl)-purine
75128-56-2

9-(2-benzoyloxyethoxymethyl)-purine

Conditions
ConditionsYield
Stage #1: purine With lithium diisopropyl amide In N,N-dimethyl-formamide at 0℃; for 0.0833333h;
Stage #2: (2-benzoyloxyethyl)oxymethyl chloride In N,N-dimethyl-formamide at 20℃; for 26h;
28%
2-chlorocyclopentanone
694-28-0

2-chlorocyclopentanone

purine
120-73-0

purine

2-(7H-Purin-7-yl)cyclopentan-1-one

2-(7H-Purin-7-yl)cyclopentan-1-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 50℃; for 24h;26%

120-73-0Related news

A miniature electrochemical detection system based on GOQDs/MWCNTs /SPCE* for determination the Purine (cas 120-73-0) in cells09/02/2019

The development of a simple, portable and accurate instrument used in the evaluation of in vitro cytotoxicity is particularly important and urgent in the field of toxicology research at present. In the current study, a miniature electrochemical detection system was constructed that integrated gr...detailed

Effects of breeds, tissues and genders on Purine (cas 120-73-0) contents in pork and the relationships between Purine (cas 120-73-0) content and other meat quality traits09/01/2019

The purine contents of animal foods are becoming widely concerned because excess intake of purine increases the risk of hyperuricemia and gout. In this study, we investigated the impacts of breed, tissue and sex on pork purine content and its correlations with multiple meat quality traits. Among...detailed

Dynamic compartmentalization of Purine (cas 120-73-0) nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma08/31/2019

Compartmentalization is vital for biological systems at multiple levels, including biochemical reactions in metabolism. Organelle-based compartments such as mitochondria and peroxisomes sequester the responsible enzymes and increase the efficiency of metabolism while simultaneously protecting th...detailed

Label-free electrochemical analysis of Purine (cas 120-73-0) nucleotides and nucleobases at disposable carbon electrodes in microliter volumes08/29/2019

We analyzed purine nucleotides in oligodeoxynucleotides (ODN) and nucleobase residues acid-hydrolyzed ODN at nanomolar concentrations in few tens of microliters of solution at commercially available unmodified graphite pencil electrodes, screen printed graphite electrodes (SPGEs) and SPGEs modif...detailed

Aromaticity of the most stable adenine and Purine (cas 120-73-0) tautomers in terms of Hückel's 4N+2 principle08/28/2019

Electron structures of the fused rings in 7H and 9H tautomers of purine and adenine follow the 4N + 2 rule; the values of pEDA, HOMA, NICS and FLU indices document their aromatic character. In the 1H and 3H tautomers, these rings contain five or seven π electrons, hence they do not follow this ...detailed

120-73-0Relevant articles and documents

Synthesis and properties of 2-guanidinopurines

Cesnek, Michal,Masojidkova, Milena,Holy, Antonin,Solinova, Veronika,Koval, Dusan,Kasicka, Vaclav

, p. 1303 - 1319 (2006)

2-Guanidinopurines were prepared as derivatives of 2,6-diamino-9-[2- (phosphonomethoxy)ethyl]-9H-purine (PMEDAP) (1), which shows an important antiviral activity. It completes earlier described synthesis of 6-guanidinopurine derivatives. The title compounds were obtained by the reaction of the corresponding 2-chloropurines with guanidine. 2- And 6-guanidinopurines were used as model compounds for determination of dissociation constants (pKa) of their ionogenic groups by capillary zone electrophoresis. The pKa values of ionogenic groups of the above compounds were compared with those of the corresponding aminopurines. The pKa of guanidino group at the purine moiety varies from 7.77 to 10.32. There is no protonation of N1-position in contrast to aminopurines. None of these compounds showed any antiviral activity.

-

Grundmann,Kreutzberger

, p. 6559 (1955)

-

Guanine, adenine, and hypoxanthine production in UV-irradiated formamide solutions: Relaxation of the requirements for prebiotic purine nucleobase formation

Barks, Hannah L.,Buckley, Ragan,Grieves, Gregory A.,Di Mauro, Ernesto,Hud, Nicholas V.,Orlando, Thomas M.

, p. 1240-1243+1159 (2010)

Relaxed requirements: We demonstrate the formation of adenine, hypoxanthine, and guanine from heated (130 °C), UV-irradiated formamide solutions in the absence of an inorganic catalyst. Evidence is also provided that "classical" HCN pathways for purine nucleobase production are also active in heated and UV-irradiated formamide reactions. (Chemical Equation Presented)

Monitoring the reactivity of formamide on amorphous SiO2 by in-situ UV-Raman spectroscopy and DFT modeling

Balucani, Nadia,Bonino, Francesca,Martra, Gianmario,Pantaleone, Stefano,Signorile, Matteo,Ugliengo, Piero

, (2020)

Formamide has been recognized in the literature as a key species in the formation of the complex molecules of life, such as nucleobases. Furthermore, several studies reported the impact of mineral phases as catalysts for its decomposition/polymerization processes, increasing the conversion and also favoring the formation of specific products. Despite the progresses in the field, in situ studies on these mineral-catalyzed processes are missing. In this work, we present an in situ UV-Raman characterization of the chemical evolution of formamide over amorphous SiO2 samples, selected as a prototype of silicate minerals. The experiments were carried out after reaction of formamide at 160 ?C on amorphous SiO2 (Aerosil OX50) either pristine or pre-calcined at 450 ?C, to remove a large fraction of surface silanol groups. Our measurements, interpreted on the basis of density functional B3LYP-D3 calculations, allow to assign the spectra bands in terms of specific complex organic molecules, namely, diaminomaleonitrile (DAMN), 5-aminoimidazole (AI), and purine, showing the role of the mineral surface on the formation of relevant prebiotic molecules.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

-

Paragraph 0714, (2016/08/03)

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

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