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Cas Database

2038-03-1

2038-03-1

Identification

  • Product Name:4-(2-Aminoethyl)morpholine

  • CAS Number: 2038-03-1

  • EINECS:218-011-6

  • Molecular Weight:130.19

  • Molecular Formula: C6H14N2O

  • HS Code:29349990

  • Mol File:2038-03-1.mol

Synonyms:Morpholine,4-(2-aminoethyl)- (6CI,7CI,8CI);1-(2-Aminoethyl)morpholine;1-Amino-2-morpholinoethane;2-(4-Morpholino)ethylamine;2-(4-Morpholinyl)ethanamine;2-(4-Morpholinyl)ethylamine;2-(Morpholin-4-yl)ethaneamine;2-Morpholino-1-ethanamine;2-Morpholinoethaneamine;2-Morpholinoethylamine;4-Morpholineethanamine;4-Aminoethylmorpholine;N-(2-Aminoethyl)morpholine;N-(b-Aminoethyl)morpholine;[2-(Morpholin-4-yl)ethyl]amine;b-Morpholinoethylamine;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC, ToxicT

  • Hazard Codes:C,T

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-(2-Aminoethyl)morpholine
  • Packaging:1g
  • Price:$ 65
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(2-Aminoethyl)morpholine >98.0%(GC)(T)
  • Packaging:500g
  • Price:$ 277
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(2-Aminoethyl)morpholine >98.0%(GC)(T)
  • Packaging:25g
  • Price:$ 36
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-(2-Aminoethyl)morpholine >98.0%(GC)(T)
  • Packaging:100g
  • Price:$ 101
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(2-Aminoethyl)morpholine
  • Packaging:50 g
  • Price:$ 40
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-(2-Aminoethyl)morpholine
  • Packaging:250 g
  • Price:$ 176
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-(2-Aminoethyl)morpholine 95%+
  • Packaging:2.500g
  • Price:$ 215
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-(2-Aminoethyl)morpholine 95%+
  • Packaging:5g
  • Price:$ 323
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:4-(2-Aminoethyl)morpholine 95%+
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  • Manufacture/Brand:ChemScene
  • Product Description:2-Morpholinoethanamine 99.95%
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Relevant articles and documentsAll total 38 Articles be found

SYNTHESIS, STRUCTURE, AND ACTION OF SOME GOSSYPOL DERIVATIVES ON THE PEROXIDATION OF THE LIPIDS OF BIOSUBSTRATES

Dalimov, D. N.,Mukhamedzhanova, E. N.,Shneivais, V. B.,Biktimirov, L.,Ismailov, A. I.,Kamaev, F. G.

, p. 603 - 607 (1989)

The synthesis has been effected of new gossypol derivatives using piperidino- and morpholinoethylamines.According to their PMR spectra, these substances exist in the keto-amine form.Their action on the peroxidation of lipids (POL) of various biosubstrates has been studied.Gossypol bis(piperidinoethylimine) and bis(morpholinoethylimine) in concentrations of 1*1E-7 - 5*1E-6 mM exert a pronounced antioxidant action on human blood serum and rat brain synaptosomes.In the same concentrations, these substances suppressed the POL in enzymatic and nonenzymatic systems of the oxidation of rat liver microsomes.

Preparation method of N-(2-aminoethyl) morpholine

-

Paragraph 0062; 0069-0072; 0073; 0080-0083, (2021/04/21)

The invention provides a preparation method of N-(2-aminoethyl) morpholine, which comprises the following steps: S1, adding ethanolamine into dichloromethane to fully dissolve, dropwise adding benzyl chloroformate into the solution, and reacting under alkaline conditions to generate an intermediate 1; S2, adding the intermediate 1 into dichloromethane, fully dissolving, dropwise adding 4toluenesulfonyl chloride, and reacting under an alkaline condition to generate an intermediate 2; S3, adding the intermediate 2 into acetonitrile to be fully dissolved, adding morpholine into the acetonitrile to generate an intermediate 3, wherein the structural formula of the intermediate 3 is shown as the following formula (3); and S4, adding the intermediate 3 into methanol, fully dissolving, and carrying out a catalytic hydrogenation reaction under the action of a catalyst to generate N-(2-aminoethyl)morpholine. According to the N-(2-aminoethyl)morpholine preparation method provided by the embodiment of the invention, the raw materials used in the reaction are cheap and easily available, the toxicity is low, the operation is simple and convenient, and the method has less three wastes and is more environment-friendly.

COMPOUND INHIBITING BUTYRYLCHOLINESTERASE

-

Page/Page column 9, (2020/07/31)

The invention concerns a compound according to formula (I), wherein 3 n 11, wherein R comprises or consists of a heterocycle comprising one tertiary amino group providing the binding of R to the rest of the molecule and at least three carbon atoms, wherein all carbon atoms of the heterocycle are unsubstituted or wherein R is a fused bicyclic compound comprising the heterocycle and one further cyclic compound.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale

, p. 304 - 317 (2019/02/07)

Cdc2-like kinase 1 (CLK1) and dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) are involved in the regulation of alternative pre-mRNA splicing. Dysregulation of this process has been linked to cancer progression and neurodegenerative diseases, making CLK1 and DYRK1A important therapeutic targets. Here we describe the synthesis of new pyrido[3,4-g]quinazoline derivatives and the evaluation of the inhibitory potencies of these compounds toward CDK5, CK1, GSK3, CLK1 and DYRK1A. Introduction of aminoalkylamino groups at the 2-position resulted in several compounds with low nanomolar affinity and selective inhibition of CLK1 and/or DYRK1A. Their evaluation on several immortalized or cancerous cell lines showed varying degree of cell viability reduction. Co-crystal structures of CLK1 with two of the most potent compounds revealed two alternative binding modes of the pyrido[3,4-g]quinazoline scaffold that can be exploited for future inhibitor design.

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model

Hoffmann, Matthias,Stiller, Carina,Endres, Erik,Scheiner, Matthias,Gunesch, Sandra,Sotriffer, Christoph,Maurice, Tangui,Decker, Michael

, p. 9116 - 9140 (2019/11/03)

In this study, the carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized with regard to a longer binding to the enzyme. A set of compounds bearing different heterocycles (e.g., morpholine, tetrahydroisoquinoline, benzimidazole, piperidine) and alkylene spacers (2 to 10 methylene groups between carbamate and heterocycle) in the carbamate residue was synthesized and characterized in vitro for their binding affinity, binding kinetics, and carbamate hydrolysis. These novel BChE inhibitors are highly selective for hBChE over human acetycholinesterase (hAChE), yielding short-, medium-, and long-acting nanomolar hBChE inhibitors (with a half-life of the carbamoylated enzyme ranging from 1 to 28 h). The inhibitors show neuroprotective properties in a murine hippocampal cell line and a pharmacological mouse model of Alzheimer's disease (AD), suggesting a significant benefit of BChE inhibition for a disease-modifying treatment of AD.

A lysosome-specific near-infrared fluorescent probe for: In vitro cancer cell detection and non-invasive in vivo imaging

Mengji, Rakesh,Acharya, Chiranjit,Vangala, Venugopal,Jana, Avijit

supporting information, p. 14182 - 14185 (2019/12/02)

Near-infrared (NIR) fluorescent probes have been developed as potential bio-materials having profound applications in diagnosis and clinical practice. Herein, we wish to disclose a highly photostable ultra-bright NIR probe for the specific detection of lysosomes in numerous cell lines. Furthermore, the applicability of the developed NIR probe was evaluated for in vivo imaging.

Process route upstream and downstream products

Process route

4-morpholinoacetonitrile
5807-02-3

4-morpholinoacetonitrile

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3.33333h;
72%
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Reflux;
72%
With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;
72%
With ethanol; sodium; toluene;
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Reflux;
2-(2-morpholin-4-ylethyl)-1H-isoindole-1,3(2H)-dione
6820-90-2

2-(2-morpholin-4-ylethyl)-1H-isoindole-1,3(2H)-dione

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With hydrazine hydrate; In ethanol; for 24h; Reflux;
95%
With hydrazine hydrate; In ethanol; at 20 ℃; Reflux;
95%
With hydrogenchloride;
With hydrazine hydrate; In ethanol; Reflux;
With hydrazine hydrate; In ethanol; for 18h; Reflux;
4-(2-benzyloxycarbonylaminoethyl)-N-morpholine

4-(2-benzyloxycarbonylaminoethyl)-N-morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In methanol; at 20 - 25 ℃; for 5h; Large scale;
91.3%
ethanolamine
141-43-5

ethanolamine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With HZSM-5; In water; at 300 ℃; Temperature;
3-(morpholin-4-yl)propionic acid hydrazide
59737-33-6

3-(morpholin-4-yl)propionic acid hydrazide

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With trifluoroacetic acid; sodium nitrite; In water; at 0 - 80 ℃;
87%
4-(2-azido-ethyl)-morpholine
660395-39-1

4-(2-azido-ethyl)-morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In methanol; at 30 ℃; for 18h; Inert atmosphere;
77%
4-morpholinoacetonitrile
5807-02-3

4-morpholinoacetonitrile

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

bis(2-morpholinylethyl)amine
200623-49-0

bis(2-morpholinylethyl)amine

Conditions
Conditions Yield
With methanol; nickel; at 50 ℃; under 88260.9 Torr; Hydrogenation;
With ammonia; nickel; Hydrogenation;
With ammonia; cobalt; at 90 ℃; under 180 Torr; Hydrogenation;
With ammonium hydroxide; cobalt catalyst; at 110 ℃; under 588406 Torr; Hydrogenation;
With methanol; ammonia; cobalt; at 85 - 95 ℃; under 110326 Torr; Hydrogenation;
With methanol; nickel; at 50 ℃; under 88260.9 Torr; Hydrogenation;
ethylenediamine
107-15-3,85404-18-8

ethylenediamine

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With sodium carbonate; In acetonitrile; for 24h; Heating;
95%
N-(2-chlorethyl)morpholine
3240-94-6

N-(2-chlorethyl)morpholine

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

Conditions
Conditions Yield
With ammonium hydroxide;
Multi-step reaction with 2 steps
1: toluene
2: aqueous HCl
With hydrogenchloride; toluene;
3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

4-(2-AMINOETHYL)MORPHOLINE
2038-03-1

4-(2-AMINOETHYL)MORPHOLINE

1,2-dimorpholylethane
1723-94-0

1,2-dimorpholylethane

Conditions
Conditions Yield
With ethylenediamine;
With ethylenediamine;

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  • Shanghai Run-Biotech Co., Ltd.
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