304-59-6

Basic information

• Product Name: Potassium sodium tartrate
• Synonyms: D-Potassiumsodiumtartrate;L(+)Potassiumsodiumtartrate;monopotassiummonosodiumtartrate;PotassiumsodiumD-tartrate;sodiumpotassium(dl)-tartrate;tartaricacid,monopotassiummonosodiumsalt;Potassium sodium tartarate;POTASSIUM SODIUM TARTRATE SOLUTION 1.5M
• CAS NO: 304-59-6
• Molecular Formula: C₄H₄O₆*K*Na
• Molecular Weight: 210.16
• EINECS: 206-156-8
• Product Categories: Food additive and acidulant
• Mol File: 304-59-6.mol

Chemical Properties

• Melting Point: 70~80℃
• Boiling Point: 100 °C
• Flash Point: 209.4 °C
• Appearance: Clear Colorless/Liquid
• Density: 1.24
• Vapor Pressure: 4.93E-08mmHg at 25°C
• Storage Temp.: Room Temperature
• Solubility: Methanol, Water
• Water Solubility: 630 g/L (20℃)
• CAS DataBase Reference: Potassium sodium tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: Potassium sodium tartrate(304-59-6)
• EPA Substance Registry System: Potassium sodium tartrate(304-59-6)

Safety Data

• Hazard Codes: C
• Statements: 35
• Safety Statements: 45-37/39-26-36/37/39
• RIDADR: UN 1824 8/PG 2
• Hazardous Substances Data: 304-59-6(Hazardous Substances Data)

Usage

Uses

1. Used in Food Industry:
Potassium sodium tartrate is used as a food additive for [application type] to enhance the texture and stability of various food products. Its E number is E337, and it has been used medicinally as a laxative.
2. Used in Pharmaceutical Industry:
Potassium sodium tartrate is used as a laxative for [application reason] to promote bowel movement and relieve constipation.
3. Used in Research:
Potassium sodium tartrate solution is used as a chelator for [application reason] to bind and remove metal ions in various research applications.
4. Used in Silvering Mirrors:
Potassium sodium tartrate is used in the process of silvering mirrors for [application reason] to facilitate the deposition of a thin layer of silver on the mirror surface.
5. Used in Analytical Chemistry:
Potassium sodium tartrate is an ingredient of Fehling's solution, which is used for [application reason] the determination of reducing sugars in solutions.
6. Used in Piezoelectricity:
Potassium sodium tartrate and mono potassium phosphate were the first materials discovered to exhibit piezoelectricity, which is used for [application reason] converting mechanical stress into electrical charge and vice versa.

Preparation

Potassium sodium tartrate, (KNaC4H4O6) may be prepared by adding 0.5 mole sodium carbonate to heated solution containing 1 mole potassium bitartrate(KHC4H5O6). (1M KHC4H4O6 : 0.5M Na2CO3). The solution is filtered while hot. This solution is then dried to precipitate solid potassium sodium tartrate, as small crystallites. Larger crystals of Rochelle salt have been grown under conditions of reduced gravity and convection on board Skylab .

Flammability and Explosibility

Notclassified

Purification Methods

Recrystallise it from distilled water (1.5mL/g) by cooling to 0o. [Beilstein 3 IV 1223.]

InChI:InChI=1/C4H6O6.K.Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2

Synthetic route

(+)-(2R,3R)-{3-Ethyl-3-[2-methoxy-6-(trimethylsilanyl)pyridin-4-yl]-oxiranyl}-methanol + Rochelle's salt (304-59-6) → (Z)-3-[2-methoxy-3-methoxymethoxymethyl-6-(trimethylsilanyl)pyridin-4-yl]pent-2-en-1-ol (412046-42-5)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	99%

diethyl ether (60-29-7) + Rochelle's salt (304-59-6) → 3-butyl-2-hepten-1-ol (163267-92-3)

Conditions	Yield
In toluene	99%

diethyl ether (60-29-7) + diisobutylaluminium hydride (1191-15-7) + Rochelle's salt (304-59-6) → 3-butyl-2-hepten-1-ol (163267-92-3)

Conditions	Yield
In toluene	99%

Rochelle's salt (304-59-6) + p-(trans-5-butyl-1,3-dioxan-2-yl)benzonitrile (74240-65-6) → p-(trans-5-butyl-1,3-dioxan-2-yl)benzaldehyde

Conditions	Yield
With diisobutylaluminium hydride In toluene	98.3%

water (7732-18-5) + Rochelle's salt (304-59-6) + methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate (213250-62-5) → 2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol (213250-63-6)

Conditions	Yield
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; toluene	97%
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; toluene	97%

Rochelle's salt (304-59-6) + methyl-2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)acetate (213250-62-5) → 2-((3R,5R)-3,5-bis(tertbutyldimethylsilyloxy)-4-methylenecyclohexylidene)ethanol (213250-63-6)

Conditions	Yield
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; water; toluene	97%
With hydrogenchloride; diisobutylaluminium hydride In dichloromethane; water; toluene	97%

[1-(Methoxy-methyl-carbamoyl)-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester + Rochelle's salt (304-59-6) → [1-Formyl-2-(1-trityl-1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

Conditions	Yield
In tetrahydrofuran; diethyl ether; water	84%

[1R-[1β(1R*,2E,4S*),[4S*],3aα,7aβ]]-Octahydro-7a -methyl-1-[1,4-dimethyl-4-[(2,24-trimethyl-1,3-dioxolan-4-yl)-2-butenyl]-4H-inden-4 -one + [3S-(3α,5β,Z)]-2-[2-methylene-3,5 bis-[(1,1-dimethylethyl)dimethylsilyloxy] cyclohexylidene]ethyldiphenylphosphine oxide + 1α,25(S),26-trihydroxycholecalciferol + potassium carbonate (584-08-7) + Rochelle's salt (304-59-6) → 1α,25S,26-trihydroxyergocalciferol

Conditions	Yield
With n-butyllithium; potassium hydrogencarbonate In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate	83%

diisobutylaluminum hydride (Dibal-H) + (S)-γ-pivaloyloxymethyl-γ-butyrolactone + dichloromethane (75-09-2) + Rochelle's salt (304-59-6) → 2-(R,S)-Hydroxy-5-(S)-(pivaloyloxymethyl)tetrahydrofuran (145164-89-2)

Conditions	Yield
In tetrahydrofuran; methanol	82%

3,3-diphenyl-2-propenal (1210-39-5) + Rochelle's salt (304-59-6) → 3,3-diphenylprop-2-en-1-ol (4801-14-3)

Conditions	Yield
With diisobutylaluminium hydride In methanol; toluene	80%
With diisobutylaluminium hydride In methanol; toluene	80%

ethyl 5-iodo-4-(methylsulfonamido)-2-(methylthio)benzoate (1456693-17-6) + Rochelle's salt (304-59-6) → N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide (1456693-19-8)

Conditions	Yield
With diisobutylaluminium hydride In toluene	80%
With diisobutylaluminium hydride In toluene	80%
With diisobutylaluminium hydride In toluene	80%
With diisobutylaluminium hydride In toluene	80%

ethyl 2-[2-(1-ethoxyethoxy)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide (198774-56-0) + Rochelle's salt (304-59-6) → 2-(2-Hydroxyethyl)-3-hydroxymethyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide (198774-57-1)

Conditions	Yield
With hydrogenchloride; diisobutylaluminium hydride In water; acetone	79%

cis-3-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-but-2-enoic acid ethyl ester + Rochelle's salt (304-59-6) → trans-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-but-2-enyl]-carbamic acid tert-butyl ester (558443-43-9)

Conditions	Yield
With diisobutylaluminium hydride In dichloromethane	77%

3-(3-benzyloxy-phenyl)-benzonitrile (893736-89-5) + Rochelle's salt (304-59-6) → 3-(3-benzyloxy-phenyl)-benzaldehyde (893736-16-8)

Conditions	Yield
With diisobutylaluminium hydride In tetrahydrofuran; hexane; water	75%

S(+)-phenylglycine + Rochelle's salt (304-59-6) + benzoyl chloride (98-88-4) → N-(2-hydroxy-1-phenylethyl)benzamide (96392-53-9)

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium chloride In tetrahydrofuran; methanol; dichloromethane; water	62%

carbon dioxide (124-38-9) + ethyl(diethylphosphono)(fluoro)acetate (2356-16-3) + (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester (1393802-40-8) + ammonium chloride + Rochelle's salt (304-59-6) → (R)-ethyl 5-((R)-1,1-dimethylethylsulfinamido)-2,4,4-trifluoro-5-(2-fluorophenyl)-hex-2-enoate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; SiO2 In water; ethyl acetate; toluene; acetonitrile	60%

4-benzylthio-2,3,5,6-tetrahydro-4-nitromethyl-4H-pyran (133762-55-7) + Rochelle's salt (304-59-6) → 4-aminomethyl-4-benzylthio-2,3,5,6-tetrahydro-4H-pyran (133762-56-8)

Conditions	Yield
In water; isopropyl alcohol	59%

(1R,3R,5R) Methyl [3,5-Bis(tert.-butyldimethylsilyloxy)-1-hydroxycyclohexane carboxylate + Rochelle's salt (304-59-6) → 1-hydroxy-1-hydroxymethylcyclohexane

Conditions	Yield
With diisobutylaluminium hydride In ethyl acetate; toluene	59%

(2R,4R)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-E-(2-carbomethoxy-vinyl)uracil + Rochelle's salt (304-59-6) → (2S,4S)-5-(3-hydroxypropenyl)-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]uracil

Conditions	Yield
With diisobutylaluminium hydride In methanol; hexane; toluene	56%

Rochelle's salt (304-59-6) + methyl benzo-2,1,3-thiadiazole-5-carboxylate → 2,1,3-benzothiadiazol-5-ylmethanol (89795-51-7)

Conditions	Yield
In diethyl ether; ethyl acetate; Petroleum ether	47%

benzyl(2-methyl-1-nitropropan-2-yl)sulfane (105780-12-9) + Rochelle's salt (304-59-6) → 2-benzylthio 2-methyl propylamine (59681-09-3)

Conditions	Yield
In water; isopropyl alcohol	46%

Upstream product

• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 849585-22-4 LACTIC ACID 
• 80-69-3 tartronic acid 
• 526-95-4 gluconic acid 
• 6556-12-3 D-Glucuronic acid 
• 7240-15-5 4,4-Dimethylcholest-8-ene-3β-ol 
• 145022-00-0 1-benzyl-3-formylpiperidine 
• 531503-39-6 (Z)-3-(2-hexyloxy-3,5-diisopropylphenyl)but-2-enal 
• 474329-85-6 4-(4-bromo-2-hydroxymethyl-6-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 50382-32-6 (2,4-dimethyl-1,3-thiazol-5-yl)methanol 
• 52423-63-9 2-(3-phenyl-5-yl-pyrrolidin-3-yl)-ethanol 
• 106429-29-2 5-(hydroxymethyl)-benzimidazole 
• 89795-51-7 2,1,3-benzothiadiazol-5-ylmethanol 
• 76632-23-0 4-(hydroxymethyl)-2-methylthiazole 
• 1074-85-7 (1H-indol-4-yl)methanol 

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