341-58-2Relevant articles and documents
Homocoupling of a Grignard Reagent toward the Synthesis of 2,2′-Bis(trifluoromethyl)-4,4′-diaminobiphenyl
Nakatani, Jiro,Nozoe, Tatsuhiro
, p. 2442 - 2446 (2021/11/13)
A new process for the synthesis of 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl (TFMB) comprising three steps has been industrially developed. The first step is the homocoupling of the Grignard reagent derived from 1-chloro-2-(trifluoromethyl)benzene with iron chloride(III) in the presence of an oxidizing agent to afford 2,2′-bis(trifluoromethyl)biphenyl. The second step is the nitration of this biphenyl to 2,2′-bis(trifluoromethyl)-4,4′-dinitrobiphenyl, and the third step is the reduction of this dinitrobiphenyl using hydrogen over Pd/C to afford TFMB. This process has been demonstrated on an industrial scale.
Preparation Method for 2,2'-Bis(Trifluoromethyl)-4,4'-Diaminobiphenyl
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Paragraph 0026-0037, (2021/07/20)
The present invention relates to a method for producing 3,3 '- bis 2,2 - diaminobiphenyl by a benzidine rearrangement reaction from' -4 bis hydrazinobenzene in high yield, and more specifically, to dissolve 4 3,3 '-' - bis hydrazinobenzene in (A) organic solvent. (B) The solution prepared in (A) is added dropwise to an inorganic acid solution while maintaining a temperature below 0 °C.30°C. When the (C) titration is completed, less than 0 °C -30°C or less is reacted. 2,2 '- Bis -4, 4' - diaminobiphenyl, which is characterized in that it comprises.
METHOD OF MANUFACTURING BIS(TRIFLUOROMEHTYL)DIAMINOBIPHENYL COMPOUND
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Paragraph 0056-0089, (2021/09/21)
To exemplary embodiments of the present invention, a bis dinitrobiphenyl compound is prepared. On the solution the bis dinitrobiphenyl based compound is reacted with an alkali sulfide. The productivity of bis diaminobiphenyl compounds can be improved.