5239-82-7

Basic information

• Product Name: Cyclopropylacetic acid
• Synonyms: 2-Cyclopropaneacetic acid;2-Cyclopropyl-acetic acid;CYCLOPROPYLACETIC ACID;RARECHEM AL BO 1300;TIMTEC-BB SBB005442;Cyclopropylaceticacid,97%;Cyclopropaneacetic acid;(Carboxymethyl)cyclopropane
• CAS NO: 5239-82-7
• Molecular Formula: C₅H₈O₂
• Molecular Weight: 100.12
• EINECS: -0
• Mol File: 5239-82-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 86-87°C 9mm
• Flash Point: 93°C
• Appearance: /
• Density: 1,076 g/cm3
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.4350
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.76±0.10(Predicted)
• BRN: 2323311
• CAS DataBase Reference: Cyclopropylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropylacetic acid(5239-82-7)
• EPA Substance Registry System: Cyclopropylacetic acid(5239-82-7)

Safety Data

• Hazard Codes: C
• Statements: 34-41-37/38-22
• Safety Statements: 26-36/37/39-45-39
• RIDADR: 3265
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 5239-82-7(Hazardous Substances Data)

Usage

Chemical Properties

colorless liquid

Uses

Cyclopropylacetic Acid is used in the synthesis of many organic compounds. Such compounds include Cyproconazole which is an agricultural fungicide and also in synthesis of potent nicotinic acid receptor agonists used in treatment of Dyslipidemia.

InChI:InChI=1/C8H20B2N6S/c1-13-5-6-14(2)9(13)11-17-12-10-15(3)7-8-16(10)4/h5-8H2,1-4H3

Synthetic route

cyclopropyl-malonic acid (5617-88-9) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
at 160℃;	98%

2-cyclopropylacetonitrile (6542-60-5) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With water; potassium hydroxide In ethanol at 90℃; for 18h;	96%
With dihydrogen peroxide; sodium hydroxide In water at 0℃; for 48h; Reflux; Inert atmosphere;	83%
With dihydrogen peroxide; sodium hydroxide In water Reflux;	81%

diiodomethane (75-11-6) + but-3-enoic acid (625-38-7) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With diethylzinc In toluene Ambient temperature;	75%
With hydrogenchloride

carbon dioxide (124-38-9) + 1,3-dioxoisoindolin-2-yl 2-cyclopropylacetate → pent-4-enoic acid (591-80-0) + cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With (1,2-dimethoxyethane)dichloronickel(II); 2.9-dimethyl-1,10-phenanthroline; silver fluoride In N,N-dimethyl acetamide at 20℃; under 5171.62 Torr; for 24h;	A 7% B 21%

diazomethane (186581-53-3, 908094-01-9) + cyclopropanecarboxylic acid chloride (4023-34-1) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With diethyl ether Erwaermen des Reaktionsprodukts mit Ag2O in Methanol und mit wss. KOH;

2-cyclopropylacetaldehyde (56105-19-2) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With silver(l) oxide

-triphenyl-phosphoran (14902-14-8) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With sodium hydroxide

β-vinyl-β-propiolactone (7379-74-0) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With 9-borabicyclo[3.3.1]nonane dimer; sodium methylate 1.) THF, r.t., 6 h; 2.) r.t., 12 h; Yield given. Multistep reaction;

cyclopropylketene (128871-21-6) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With water Rate constant;

carbon dioxide (124-38-9) + cyclopropylcarbinyl bromide (7051-34-5) → pent-4-enoic acid (591-80-0) + cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With magnesium In tetrahydrofuran at -120 - -30℃; Yield given. Yields of byproduct given;

tetrachloromethane (56-23-5) + Bis(cyclopropylacetyl) peroxide (1607-28-9) → carbon dioxide (124-38-9) + cyclopropyl-acetic acid cyclopropylmethyl ester (61919-47-9) + cyclopropylacetic acid (5239-82-7)

1-cyclopropylethanol (2566-44-1) + aqueous potassium permanganate solution → cyclopropylacetic acid (5239-82-7) + cyclopropanecarboxylic acid (1759-53-1)

diethyl cyclopropylmalonate (42392-68-7) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH View Scheme

1-cyclopropylethanol (2566-44-1) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: durch Dehydrierung an einem Kupfer-Silber-Katalysator 2: Ag2O View Scheme

jones reagent + 2-cyclopropylacetaldehyde (56105-19-2) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With sulfuric acid In water; acetone
With sulfuric acid In water; acetone

2-(cyclopropanemethyl)-1,3-dithiane → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran 2: sulfuric acid / water; acetone View Scheme

Cyclopropylacetylene (6746-94-7) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
Stage #1: Cyclopropylacetylene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: With 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran for 2h; Stage #3: With oxone In acetone at 50℃; for 12h;	475.6 mg

2-(2-cyclopropylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1432491-43-4) → cyclopropylacetic acid (5239-82-7)

Conditions	Yield
With oxone||potassium monopersulfate triple salt; water In acetone at 50℃; for 12h; Inert atmosphere;	475 mg

cyclopropylacetic acid (5239-82-7) + 7-tert-butyl-3,3-dimethyl-2,3-dihydrobenzo[b]furan (124435-71-8) → 1-(7-tert-butyl-2,3-dihydro-3,3-dimethyl-5-benzofuranyl)-2-cyclopropylethan-1-one

Conditions	Yield
With trifluoroacetic anhydride at -20 - 20℃;	100%

1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole (885232-51-9) + cyclopropylacetic acid (5239-82-7) → 1-{4-[3-(4-chloro-benzyl)-6-fluoro-2-phenoxymethyl-3H-benzoimidazol-5-yl]-piperazin-1-yl}-2-cyclopropyl-ethanone

Conditions	Yield
Stage #1: cyclopropylacetic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0166667h; Stage #2: 1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole In N,N-dimethyl-formamide at 20℃; for 22h;	100%

[3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)benzylamino]-acetic acid ethyl ester hydrochloride (1310036-75-9) + cyclopropylacetic acid (5239-82-7) → {(2-cyclopropyl-acetyl)-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-amino}-acetic acid ethyl ester (1310038-17-5)

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃;	100%

cyclopropylacetic acid (5239-82-7) + 5-amino-2-bromo-benzoic acid methyl ester (6942-37-6) → methyl 2-bromo-5-(2-cyclopropylacetamido)benzoate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;	100%

cyclopropylacetic acid (5239-82-7) → cyclopropylacetyl chloride (54322-65-5)

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25℃; for 4h;	99.6%
With oxalyl dichloride In dichloromethane at 20℃; for 4h;	98%
With thionyl chloride In dichloromethane at 60℃; for 2h;	90%

methyl (2R,12Z,13aS,14aR,16aS)-6-amino-5,16-dioxo-2-[(5-pyridin-2-ylthieno[3,2-b]pyridin-7-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate (884538-52-7) + cyclopropylacetic acid (5239-82-7) → methyl (2R,12Z,13aS,14aR,16aS)-6-[(cyclopropylacetyl)amino]-5,16-dioxo-2-[(5-pyridin-2-ylthieno[3,2-b]pyridin-7-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 15.5h;	99%

C39H49BrN6O9S (1219511-65-5) + cyclopropylacetic acid (5239-82-7) → C39H47BrN6O8S (1219511-75-7)

Conditions	Yield
Stage #1: C39H49BrN6O9S With hydrogenchloride In dioxanes at 20℃; for 1h; Stage #2: cyclopropylacetic acid With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 18h;	99%

cyclopropylacetic acid (5239-82-7) + 4-bromo-N2-methylbenzene-1,2-diamine (337915-79-4) → 6-bromo-2-(cyclopropylmethyl)-1-methyl-1H-benzimidazole (1447911-05-8)

Conditions	Yield
Stage #1: cyclopropylacetic acid; 4-bromo-N2-methylbenzene-1,2-diamine With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: With acetic acid at 80℃; for 1h;	96%

cyclopropylacetic acid (5239-82-7) + (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol (1630067-58-1) → (R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 2-cyclopropylacetate (1630067-83-2)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 7.5h; Inert atmosphere;	95.4%

methyl (2R,6S,12Z,13aS,14aR,16aS)-6-amino-5,16-dioxo-2-[(2-pyridin-2-ylthieno[2,3-d]pyrimidin-4-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate (884538-66-3) + cyclopropylacetic acid (5239-82-7) → methyl (2R,6S,12Z,13aS,14aR,16aS)-6-[(cyclopropylacetyl)amino]-5,16-dioxo-2-[(2-pyridin-2-ylthieno[2,3-d]pyrimidin-4-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate

Conditions	Yield
Stage #1: methyl (2R,6S,12Z,13aS,14aR,16aS)-6-amino-5,16-dioxo-2-[(2-pyridin-2-ylthieno[2,3-d]pyrimidin-4-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate; cyclopropylacetic acid With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 15h; Stage #2: With citric acid In dichloromethane; ethyl acetate pH=4.5;	95%

2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (766545-20-4) + cyclopropylacetic acid (5239-82-7) → 2-chloro-6-(cyclopropylacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Conditions	Yield
Stage #1: cyclopropylacetic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	95%

cyclopropylacetic acid (5239-82-7) + (±)-(2R,3R)-2-azido-3-phenyl-3-hydroxypropionic acid methyl ester → (±)-(2R,3R)-2-azido-3-(2-cyclopropylacetoxy)-3-phenylpropionic acid methyl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Steglich Esterification;	95%

cyclopropylacetic acid (5239-82-7) + (±)-(2R,3R)-2-azido-3-hydroxy-3-(3-methoxyphenyl)propionic acid methyl ester → (±)-(2R,3R)-2-azido-3-(2-cyclopropylacetoxy)-3-(3-methoxyphenyl)propionic acid methyl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Steglich Esterification;	94%

cyclopropylacetic acid (5239-82-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-cyclopropyl-N-methoxy-N-methyl-acetamide (227322-00-1)

Conditions	Yield
Stage #1: cyclopropylacetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 25℃; for 1h; Inert atmosphere; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 25℃; for 12h;	93.96%
Stage #1: cyclopropylacetic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane	89%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	84%

cyclopropylacetic acid (5239-82-7) + aniline (62-53-3) → 2-cyclopropyl-N-phenylacetamide (5687-69-4)

Conditions	Yield
Stage #1: cyclopropylacetic acid; aniline With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.5h; Inert atmosphere; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	93%
With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate at 96 - 100℃; for 7h; chemoselective reaction;	42%

cyclopropylacetic acid (5239-82-7) + dimedone (126-81-8) → 2-(2-cyclopropylacetyl)-5,5-dimethylcyclohexane-1,3-dione (908117-02-2)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16.2h;	92%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; for 14h;	85%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃;	85%

cyclopropylacetic acid (5239-82-7) + (2R,3R)-2-azido-3-phenyl-3-hydroxypropionic acid methyl ester (130517-92-9) → (2R,3R)-2-azido-3-(2-cyclopropylacetoxy)-3-phenylpropionic acid methyl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Steglich Esterification;	92%

cyclopropylacetic acid (5239-82-7) + (2S,3S)-2-azido-3-phenyl-3-hydroxypropionic acid methyl ester (133179-94-9) → (2S,3S)-2-azido-3-(2-cyclopropylacetoxy)-3-phenylpropionic acid methyl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h; Steglich Esterification;	92%

cyclopropylacetic acid (5239-82-7) + (R)-tert-butyl 3-methylpiperazine-1-carboxylate (163765-44-4) → (R)-tert-butyl 4-(2-cyclopropylacetyl)-3-methylpiperazine-1-carboxylate

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	92%
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h;	92%

1,2,3-Benzotriazole (95-14-7) + cyclopropylacetic acid (5239-82-7) → 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-cyclopropylethan-1-one

Conditions	Yield
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: cyclopropylacetic acid for 6h; Inert atmosphere; Cooling with ice;	92%
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In dichloromethane at 20℃; for 0.5h; Stage #2: cyclopropylacetic acid In dichloromethane at 20℃; for 4h;	91%

cyclopropylacetic acid (5239-82-7) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1,1'-carbonyldiimidazole → 2-cyclopropyl-N-methoxy-N-methyl-acetamide (227322-00-1)

Conditions	Yield
Stage #1: cyclopropylacetic acid; 1,1'-carbonyldiimidazole In dichloromethane at 15 - 25℃; for 2h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20 - 25℃; for 15h;	90.5%

cyclopropylacetic acid (5239-82-7) → methyl cyclopropylacetate (34108-21-9)

Conditions	Yield
With sulfuric acid In methanol	90%
Multi-step reaction with 2 steps 1: (COCl)2, DMF / benzene / 3 h / Ambient temperature 2: pyridine / Ambient temperature View Scheme

cyclopropylacetic acid (5239-82-7) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl 2-bromo-2-cyclopropylacetate

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In diethyl ether at 20℃; for 5h; Inert atmosphere;	90%

methyl (2R,6S,12Z,13aS,14aR,16aS)-6-amino-5,16-dioxo-2-[(2-pyridin-2-ylthieno[3,2-d]pyrimidin-4-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate (884538-80-1) + cyclopropylacetic acid (5239-82-7) → methyl (2R,6S,12Z,13aS,14aR,16aS)-6-[(cyclopropylacetyl)amino]-5,16-dioxo-2-[(2-pyridin-2-ylthieno[3,2-d]pyrimidin-4-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylate

Conditions	Yield
With dimethyl amine; triethylamine; HATU at 50℃; for 1.5h;	89%

cyclopropylacetic acid (5239-82-7) + benzyl bromide (100-39-0) → benzyl 2-cyclopropylacetate (59698-18-9)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	89%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 90℃; Inert atmosphere;

cyclopropylacetic acid (5239-82-7) + 8-((3R,4S)-4-methylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine dihydrobromide → 2-cyclopropyl-1-((3S,4R)-3-methyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)ethanone (1428243-48-4)

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 16h;	89%

cyclopropylacetic acid (5239-82-7) + N-β-Z-L-diaminopropionic acid methyl ester (87768-65-8) → C17H22N2O5

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 1h;	87%

dimethylenecyclourethane (497-25-6) + cyclopropylacetic acid (5239-82-7) → 3-(2-cyclopropylacetyl)oxazolidin-2-one (1330681-58-7)

Conditions	Yield
Stage #1: dimethylenecyclourethane; cyclopropylacetic acid With lithium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: With pivaloyl chloride; triethylamine In tetrahydrofuran at 0 - 20℃; for 2.33333h; Inert atmosphere;	87%

Upstream product

• 186581-53-3 diazomethane 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 75-11-6 diiodomethane 
• 625-38-7 but-3-enoic acid 
• 128871-21-6 cyclopropylketene 
• 124-38-9 carbon dioxide 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 56-23-5 tetrachloromethane 
• 1607-28-9 Bis(cyclopropylacetyl) peroxide 
• 56105-19-2 2-cyclopropylacetaldehyde 
• 1432491-43-4 2-(2-cyclopropylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 6746-94-7 Cyclopropylacetylene 
• 2566-44-1 1-cyclopropylethanol 
• 42392-68-7 diethyl cyclopropylmalonate 

Downstream Products

• 1028992-04-2 1-(4-((4-chlorophenyl)(2,4-dichlorophenyl)methyl)piperazin-1-yl)-2-cyclopropylethanone 
• 1029799-37-8 3-(2-cyclopropyl-acetyl)-2-(tetrahydropyran-4-yl)-thiazolidine-4-carboxylic acid [4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-yl]-amide 
• 1054611-65-2 C₃₀H₃₆N₄O₄ 
• 1089133-34-5 benzyl 4-cyclopropyl-3-oxobutanoate 
• 1204301-53-0 4-{3-[1-(5-cyclopropylmethyl-[1,2,4]oxadiazol-3-yl)piperidin-4-yl]propoxy}-N-((R)-2-hydroxy-1-methylethyl)-2-methylbenzamide 
• 1274888-53-7 1-(2-cyclopropyl-acetyl)-piperidine-4-carboxylic acid (4-isopropyl-phenyl)-amide 
• 1310038-19-7 {(2-cyclopropyl-acetyl)-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-amino}-acetic acid 
• 1310038-17-5 {(2-cyclopropyl-acetyl)-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-amino}-acetic acid ethyl ester 
• 227322-00-1 2-cyclopropyl-N-methoxy-N-methyl-acetamide 
• 1352754-36-9 3-[(S)-1-(4-bromo-phenyl)-ethyl]-6-cyclopropylmethyl-6-(2-methyl-allyl)-[1,3]oxazinan-2-one 
• 1352754-34-7 4-[(S)-1-(4-bromo-phenyl)-ethylamino]-1-cyclopropyl-butan-2-one 
• 1352754-35-8 1-[(S)-1-(4-bromo-phenyl)-ethylamino]-3-cyclopropylmethyl-5-methyl-hex-5-en-3-ol 
• 1352754-37-0 3-[(S)-1-(4-bromo-phenyl)-ethyl]-6-cyclopropylmethyl-6-(2-methyl-oxiranylmethyl)-[1,3]oxazinan-2-one 
• 1352754-39-2 3-[(S)-1-(4-bromo-phenyl)-ethyl]-(S)-6-cyclopropylmethyl-6-(2-hydroxy-2-methyl-propyl)-[1,3]oxazinan-2-one 

Relevant articles and documents

Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides

A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)?B bond oxidation. This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcohols, and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodology was further highlighted by the preparation of pharmaceutical molecules.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.