608-36-6

Basic information

• Product Name: meso-2,3-Dibromosuccinic acid
• Synonyms: meso-2,3-Dibromosuccinicacid,98%;meso-2,3-Dibromosuccinic acid;MESO-2,3-Dibromosuccinic acid ,99%;2,3-dibroMosuccinate;Meso-2,3-DibroMosuccini;Butanedioic acid, 2,3-dibroMo-,(2R,3S)-rel-;2,3-DibroM succinic acid;Meso-2,3-DibroMosuccinic acid 98%
• CAS NO: 608-36-6
• Molecular Formula: C₄H₄Br₂O₄
• Molecular Weight: 275.88
• EINECS: 208-396-9
• Product Categories: Carboxylic Acid Monomers;Monomers;Polymer Science
• Mol File: 608-36-6.mol

Chemical Properties

• Melting Point: 288-290 °C(lit.)
• Boiling Point: 262.4 °C at 760 mmHg
• Flash Point: 112.5 °C
• Appearance: White to pale yellow to beige/Powder
• Density: 2.486 g/cm³
• Vapor Pressure: 0.00323mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: 20 g/L (17°C)
• PKA: pK1:1.51;pK2:2.71 (20°C)
• Water Solubility: 20 g/L (17 ºC)
• Merck: 14,3029
• BRN: 1725173
• CAS DataBase Reference: meso-2,3-Dibromosuccinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: meso-2,3-Dibromosuccinic acid(608-36-6)
• EPA Substance Registry System: meso-2,3-Dibromosuccinic acid(608-36-6)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-24/25
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 608-36-6(Hazardous Substances Data)

Usage

Chemical Properties

white to pale yellow-beige powder

Uses

meso-2,3-dibromosuccinic acid is used in organic synthesis & pharmaceutical intermediate.

Purification Methods

Crystallise the acid from distilled water, keeping the temperature below 70o. [Beilstein 2 IV 1930.]

InChI:InChI=1/C4H4Br2O4/c5-1(3(7)8)2(6)4(9)10/h1-2H,(H,7,8)(H,9,10)/p-2/t1-,2+

Upstream product

• 110-17-8 (2E)-but-2-enedioic acid 
• 45669-18-9 1,2-Dibromosuccinic anhydride 
• 7732-18-5 water 
• 108-31-6 maleic anhydride 
• 5926-51-2 bromomaleic anhydride 
• 584-99-6 trans-2-bromobutenedioic acid 
• 644-80-4 cis-2-bromobutenedioic acid 
• 23220-52-2 (2S,3R)-3-aminoaspartic acid 
• 110-15-6 succinic acid 
• 78209-71-9 dibromosuccinic acid 
• 110-16-7 maleic acid 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 67-64-1 acetone 

Downstream Products

• 644-80-4 cis-2-bromobutenedioic acid 
• 110-17-8 (2E)-but-2-enedioic acid 
• 53079-45-1 racem-2,3-bis-benzylamino-succinic acid 
• 88393-56-0 N,N'-dibenzyltartramide 
• 51575-86-1 dimethyl 2,3-dibromobutane-1,4-dicarboxylate 
• 142-45-0 Acetylenedicarboxylic acid 
• 584-99-6 trans-2-bromobutenedioic acid 
• 102457-84-1 meso-2,3-bis-(benzyl-methyl-amino)-succinic acid 
• 66221-33-8 N,N'-diallyl-mesodiaminosuccinic acid 
• 14464-17-6 N,N-dibenzyl-aspartic acid 
• 55645-40-4 (2R,3S)-2,3-bis(benzylamino)succinic acid 
• 88393-56-0 meso-N,N'-dibenzyl tartramide 
• 5926-51-2 bromomaleic anhydride 

Relevant articles and documents

Synthesis method of o-Dibromo compound

The present invention discloses a synthesis method of o-dibromo compounds, said synthesis method comprising the following steps: preparation of olefins, brominated salts and a mixed solution of bromate; to the mixed solution of dropwise addition of hydrochloric acid solution for reaction; to the end of the reaction, the extraction of o-dibromo compounds in the reaction product; the synthesis method to inexpensive brominated salts (industrial or recycled brominated salts) and bromate as a bromine source, enhance the full use of applicable resources; after the end of the reaction after a simple filtration treatment to obtain a sufficient purity of the product, It can reduce production costs; at the same time, facilitate the transportation and storage of raw materials, and improve the working environment. The synthesis method of the present invention is simple and easy to operate, high safety, small pollution, simple post-treatment, low production cost, product yield and purity can meet the production needs, is both cost advantages and safety and environmental advantages of the industrializable process.

Method of treating DBA mother liquor

The present invention relates to a method of treating a DBA mother liquor, wherein a small amount of a reagent is used, high DBA yield is provided, and waste is less.

Preparation method of butynedioic acid

The invention discloses a preparation method of butynedioic acid. The method comprises the following steps of: (1) firstly, carrying out water-free and oxygen-free treatment on a closed reaction kettle; (2) putting calcium carbide, a solvent, a catalyst and an auxiliary agent into the reaction kettle, introducing carbon dioxide into the reaction kettle, and heating and pressurizing for reaction; (3) separating the reacted mixture obtained in the step (2) to obtain a liquid mixture, and adding a KOH solution into the liquid mixture; stirring to separate out a white precipitate; and dissolving the white precipitate in hot water, acidifying with concentrated sulfuric acid, cooling, separating out the white precipitate, and filtering to obtain the product. The synthesis method disclosed by theinvention is relatively environment-friendly and low in production cost.

Preparation method of 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid

The invention relates to a preparation method of 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid, comprising the steps of subjecting fumaric acid, bromine and hydrobromic acid to additive reaction to generate meso-2,3-dDibromosuccinic acid, subjecting the meso-2,3-dDibromosuccinic acid, benzylamine and a strong base to aminating reaction to generate dibenzylamino salt, subjecting the dibenzylamino salt and triphosgene to cyclization to generate the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid. The fumaric acid is subjected to addition, and then substitution and cyclization are performed to obtain the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid, and detection shows that HPLC (high-performance liquid chromatography) content of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid may reach 98-99%. The preparation method has the advantages that hydrobromic acid is added for bromination additive reaction, the concentration and reaction temperature of the hydrobromic acid are optimized, and bromine loss is more reduced; amination mother liquid is used in amination, the cost is saved, and product yield is increased; in ring-closure reaction, pH and reaction product concentration are decreased, the yield of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid is increased greatly, and the quality of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid is improved; experiments verify that through process innovation, production cost is reduced greatly, production efficiency is improved, and the process is energy efficient and environmentally friendly.

Towards the cis-bromination of double bonds

The bromination of olefins yielding a trans-1,2-dibromo-product was studied. Reagents were proposed to brominate the double bonds of cis-olefins mildly and stereospecifically. Reagents delivering two bromine atoms to the same side of olefins through a cyclic six-membered transition state were studied.

Kinetic study of the Ce(III)-, Mn(II)-, or ferroin-catalyzed Belousov-Zhabotinsky reaction with pyruvic acid

Ce(III)-, Mn(II)-, or ferroin (Fe(phen)32+)-catalyzed reaction of bromate ion and pyruvic acid (PA) or its dimer exhibits oscillatory behavior. Both the open-chain dimer (parapyruvic acid, γ-methyl-γ-hydroxyl-α-keto-glutaric acid, DP

Synthesis of Pyrazinamide

The key intermediate, pyrazinoic acid (III) in the synthesis of pyrazinamide has been prepared starting from 2,3-dibromsuccinic acid.