6271-78-9Relevant articles and documents
TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
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, (2018/03/25)
Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.
Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide
Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.
supporting information, p. 1060 - 1063 (2016/10/17)
A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.
Photocatalytic degradation of imidacloprid by phosphotungstic acid supported on a mesoporous sieve MCM-41
Feng, Changgen,Li, Yanzhou,Liu, Xia
experimental part, p. 127 - 132 (2012/03/09)
Solid catalysts consisting of polyoxometalates (POM) namely phosphotungstic acid H3PW12O40 (HPW) supported on a mesoporous sieve MCM-41 have been prepared and characterized by FT-IR, X-ray diffraction, nitrogen adsorption and high resolution transmission electron microscope (HRTEM). The HPW/MCM-41 with different HPW loadings from 10 to 60 wt% possess large specific surface area and rather uniform mesopores. Keggin structure of HPW retains on the prepared composite catalysts. The photocatalytic performance of HPW/MCM-41 was examined by degradation of a durable pesticide imidacloprid. It is found that the prepared photocatalysts exhibit high activity under irradiation of 365 nm monochromatic light. For 50 mL of imidacloprid (10 mg/L), conversion of imidacloprid using 20 mg of HPW/MCM-41 with 50 wt% loading level and calcined at 300°C reaches 58.0% after 5 h irradiation. Copyright