
Tetrahedron Letters p. 5257 - 5260 (1996)
Update date:2022-08-05
Topics:
Parlow, John J.
Quaternary ammonium exchange resins (Amberlite IRA-900) were prepared that contained each a mixture of ten aryloxides and heteroaryloxides. The feasibility of generating combinatorial libraries containing aryl and heteroaryl ethers was demonstrated by reacting the resin's with a single electrophile (n-butyl bromide) to afford mixtures of ether products. The advantages of using quaternary ammonium exchange resins over solution phase chemistry to prepare this library are discussed.
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