Study on the kinetics of the reaction between diethyl ester of 1-amino-methyl-ethanephosphonic acid and phenyl isocyanate

Article abstract of DOI:10.1080/10426509708031574

The kinetics of the reaction between O,O-diethyl ester of 1-amino-1-methyl-ethane phosphonic acid and phenylisocyanate, producing diethyl ester of 1-methyl-1-(N-phenylcarbamoyl-amino)ethane phosphonic acid is studied by IR spectroscopy. It is established that the reaction is of second order. The probable scheme of the reaction mechanism is suggested. The rate constant k of the initial stage of the reaction is determined. It is established that the rate constant is increased at the advanced stage of the process. The observed enhancement is ascribed to the autocalalytic effect of the reaction product.