Synthesis and Antimitogenic Activities of Four Analogues of Cyclosporin A Modified in the 1-Position

Article abstract of DOI:10.1021/jm00156a014

Cyclosporin A (CSA,1), an immunosuppressive cyclic undecapeptide, contains a unique N-methylated amino acid, (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(N-methylamino)-6-octenoic acid, called both C-9-ene and MeBmt <(4R)-N-methyl-4-butenyl-4-methylthreonine> that