Synthesis and Antimitogenic Activities of Four Analogues of Cyclosporin A Modified in the 1-Position

DOI: 10.1021/jm00156a014

Source and publish data:

Journal of Medicinal Chemistry p. 978 - 984 (1986)

Update date:2022-09-26

Topics:

Authors:

Rich, Daniel H.

Dhaon, Madhup K.

Dunlap, Brian

Miller, Stephen P. F.

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Article abstract of DOI:10.1021/jm00156a014

Cyclosporin A (CSA,1), an immunosuppressive cyclic undecapeptide, contains a unique N-methylated amino acid, (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(N-methylamino)-6-octenoic acid, called both C-9-ene and MeBmt <(4R)-N-methyl-4-butenyl-4-methylthreonine> that

Full text of DOI:10.1021/jm00156a014

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