Lewis acid promoted three-component reactions of aziridines, arenes and aldehydes: an efficient and diastereoselective synthesis of cis-1,4-disubstituted tetrahydroisoquinolines

DOI: 10.1016/j.tet.2015.06.013

Source and publish data:

Tetrahedron p. 6290 - 6299 (2015)

Update date:2022-08-15

Topics:

Authors:

Xing, Siyang

Ren, Jing

Wang, Kui

Cui, Hong

Li, Wenrui

Yan, Han

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Article abstract of DOI:10.1016/j.tet.2015.06.013

Abstract A new Lewis acid promoted three-component reaction between the aziridine, arene and aldehyde has been developed. This reaction involves sequential ring opening of aziridine and Pictet-Spengler condensation and gives a broad range of cis-1,4-disub

Full text of DOI:10.1016/j.tet.2015.06.013

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