Synthesis and Antitumor Activity of Analogues of Ifosfamide Modified in the N-(2-Chloroethyl) Group

DOI: 10.1021/jm00396a036

Source and publish data:

Journal of Medicinal Chemistry p. 226 - 230 (1988)

Update date:2022-08-02

Topics:

Authors:

Misiura, Konrad

Kinas, Ryszard W.

Stec, Wojciech J.

Kusnierczyk, Halina

Radzikowski, Czeslaw

Sonoda, Akio

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Article abstract of DOI:10.1021/jm00396a036

A series of 3-(2-chloroethyl)-N-(2-X-ethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxides with various X substituents have been prepared by cyclization of racemic ifosfamide or its enantiomers with sodium hydride and subsequent treatment of intermed

Full text of DOI:10.1021/jm00396a036

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