Journal of Medicinal Chemistry p. 226 - 230 (1988)
Update date:2022-08-02
Topics:
Misiura, Konrad
Kinas, Ryszard W.
Stec, Wojciech J.
Kusnierczyk, Halina
Radzikowski, Czeslaw
Sonoda, Akio
A series of 3-(2-chloroethyl)-N-(2-X-ethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxides with various X substituents have been prepared by cyclization of racemic ifosfamide or its enantiomers with sodium hydride and subsequent treatment of intermed
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