Bioorganic and Medicinal Chemistry Letters p. 2497 - 2500 (2003)
Update date:2022-07-29
Topics: 2-Aryl
Hodgetts, Kevin J.
Yoon, Taeyoung
Huang, Jianhua
Gulianello, Michael
Kieltyka, Andrzej
Primus, Renee
Brodbeck, Robbin
De Lombaert, Stephane
Doller, Dario
The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents
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