REACTION D'OXIMATION DES CETONES IV. CONSTANTES D'EQUILIBRE DE FORMATION DES CARBINOLAMINES INTERMEDIAIRES: DETERMINATION ET EFFETS DE STRUCTURE

Article abstract of DOI:10.1016/S0040-4020(01)90551-4

The equilibrium constants of formation, K₁, of carbinolamines resulting from the addition of hydroxylamine to 19 ketones, - 5 aliphatic, 5 aromatic and 9 cyclanic -, have been measured at 25 deg C in water/methanol 60/40 v/v.A general method of determination of K₁ is described.The variations of equilibrium constant are discussed in terms of torsional and nonbonding steric effects which are the main factors of reactivity for saturated ketones.