PYRIMIDINES. PART 57. A VERSATILE SYNTHESIS OF PYRIMIDOPYRIMIDINE-2,4,5-TRIONE DERIVATIVES

Article abstract of DOI:10.3987/R-1986-08-2293

Synthesis of pyrimido<4,5-d>pyrimidine derivatives (2-5) was effected by cyclization of 6-amino-5-carbamoyluracil derivatives (1) with one-carbon reagents such as dimethylformamide dimethylacetal, acid anhydrides, and N,N'-carbonyldiimidazole.