Journal of Medicinal Chemistry p. 1210 - 1214 (1987)
Update date:2022-07-29
Topics:
Pavia, Michael R.
Taylor, Charles P.
Hershenson, Fred M.
Lobbestael, Sandra J.
The anticonvulsant effect of a series of 6-alkoxy-N,N-disubstituted-2-pyridinamines is described. An investigation was carried out to optimize the activity/side-effect ratio in this series of compounds. The most desirable profile was seen with 1-<6-(2-methylpropoxy)-2-pyridinyl>piperazine, 6, and this compound was selected for a more complete pharmacological evaluation. Overall, 6 has a pharmacological profile that is very similar to that of diphenylhydantoin (phenytoin). While nearly equipotent to phenytoin, animal studies suggest a fairly short duration of action. In addition, 6 exhibited some troublesome side effects including central nervous system depression and hypothermia.
View MoreJiangxi Huashi Pharmaceutical Co., Ltd
Contact:+86-795-4509628
Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
Chengdu NoVi Biotechnology Co., Ltd.(expird)
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Contact:+86-10-59484199
Address:No.58-A1026 Liangguan Street
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)
Contact:051989185693
Address:NO 217 huangshan Rd ,Changzhou
Jinan Baozhao Pharmaceutical Co., Ltd
Contact:0086-531-86397156 82371858 82371868
Address:Huaneng Road, Jinan, Shandong ,China
Doi:10.1016/S0040-4020(01)82071-8
(1986)Doi:10.1039/b803235a
(2008)Doi:10.1039/c39920001033
(1992)Doi:10.1016/S0040-4039(00)84902-3
(1986)Doi:10.1021/ja00095a014
(1994)Doi:10.1016/S0040-4020(99)00507-4
(1999)
