Mechanism, Biological Relevance, and Structural Requirements for Thiolate Additions to Bicyclomycin and Analogues: A Unique Latent Michael Acceptor System

DOI: 10.1021/ja00247a032

Source and publish data:

Journal of the American Chemical Society p. 4028 - 4035 (1987)

Update date:2022-08-05

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Authors:

Williams, Robert M.

Tomizawa, Kohtaro

Armstrong, Robert W.

Dung, Jen-Sen

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Article abstract of DOI:10.1021/ja00247a032

Several bicyclomycin analogues based on the 8,10-diaza-5-methylene-2-oxabicyclo<4.2.2>decane-7,9-dione ring system have been synthesized and examined for thiolate addition to the C-5 exo-methylene group.The results indicate that the minimum structural req

Full text of DOI:10.1021/ja00247a032

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