Journal of Medicinal Chemistry p. 1543 - 1549 (1987)
Update date:2022-07-29
Topics:
Hermecz, Istvan
Vasvari-Debreczy, Lelle
Horvath, Agnes
Balogh, Maria
Koekoesi, Jozsef
et al.
New types of bronchodilator agents, bi- and tricyclic nitrogen bridgehead compounds with a pyrimidin-4(3H)-one ring, were synthesized and evaluated for bronchodilator activity against serotonin-, histamine-, and acetylcholine-induced spasms in the guinea pig Konzett-Roessler test.The structure-activity relationships are discussed.The effects of some bi- and tricyclic derivatives on the human bronchus were also investigated.The homologous tricyclic compounds 68 and 69 were tested on isolated guinea pig ileum and trachea, and the effects of compound 69 were investigated in pilocarpine-treated dogs.Azepino<2,1-b>quinazoline (69;CHINOIN-1289) was selected for further biochemical and clinical investigations.
View MoreShanghai Minstar Chemical Co., Ltd
website:http://www.minstargroup.com
Contact:86-21-18019205509
Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Changsha Nutritopper Bio Technology Co.,Ltd.
Contact:+86-731-87803543
Address:East 1st Street, Baima Road, Ningxiang County
Shenyang NovPharm Technology Co., Ltd.
Contact:.+86-24-24165786
Address:Room 306, Hongjin Mansion, No. 36-1, Wanliutang Rd., Shenhe District, Shenyang, Liaoning, P.R.C.
Contact:+86-28-88523492
Address:714rooms of Time Square, Pujiang County
Doi:10.1039/jr9600001370
(1960)Doi:10.1021/jo00391a018
(1987)Doi:10.1007/s11172-007-0214-x
(2007)Doi:10.1021/ol802302x
(2008)Doi:10.1021/jacs.9b12328
(2020)Doi:10.1016/S0040-4039(00)84640-7
(1986)
