SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. A MODIFIED von NIEMENTOWSKI QUINOLINE SYNTHESIS FROM ANTHRANILAMIDES

Article abstract of DOI:10.1016/S0040-4039(00)85201-6

Anthranilamides 1, A = NR2 derived from benzamides by directed ortho metalationamination, are converted into the corresponding imines 4 which upon treatment with LDA lead to substituted 4-quinolones 5 thus providing a general new quinoline synthesis (Tabl