PREPARATION OF (+/-)-α-ALKYLATED AMINO ACID DERIVATIVES VIA IMIDAZOLES

Article abstract of DOI:10.1016/S0040-4039(00)94242-4

Photooxidation of N-methoxy-2,4-disubstituted imidazoles, readily available by way of a three component cyclization followed by O-alkylation, leads to stable acylimines which react with various organomethalics to afford α, α-disubstituted amino acid bis-a