
Journal of Medicinal Chemistry p. 150 - 153 (1988)
Update date:2022-07-30
Topics:
DeCraw, J. I.
Colwell, W. T.
Brown, V. H.
Sato, M.
Kisliuk, R. L.
et al.
The syntheses of 8-deazahomofolic acid and its tetrahydro derivative, potential inhibitors of thymidylate synthase (TS) and other folate related enzymes, are described.Wittig condensation of 2-acetamido-6-formyl-4-pyrimidinol with the triphenylphosphine y
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