Synthesis and Biological Evaluation of 8-Deazahomofolic Acid and Its Tetrahydro Derivative

DOI: 10.1021/jm00396a022

Source and publish data:

Journal of Medicinal Chemistry p. 150 - 153 (1988)

Update date:2022-07-30

Topics:

Authors:

DeCraw, J. I.

Colwell, W. T.

Brown, V. H.

Sato, M.

Kisliuk, R. L.

et al. et al.

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Article abstract of DOI:10.1021/jm00396a022

The syntheses of 8-deazahomofolic acid and its tetrahydro derivative, potential inhibitors of thymidylate synthase (TS) and other folate related enzymes, are described.Wittig condensation of 2-acetamido-6-formyl-4-pyrimidinol with the triphenylphosphine y

Full text of DOI:10.1021/jm00396a022

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