THE STRUCTURE OF AN ANTIBIOTIC, DITYROMYCIN

Article abstract of DOI:10.1016/S0040-4039(00)82090-0

Dityromycin is a peptide antibiotic isolated from the culture broth of the soil microorganism, Streptomyces sp. strain No.AM-2504, showing activities against Bacillus, Corynebacterium, and Clostridium.Dityromycin was clarified to be composed of N-MeVal, Pro, Val, Phenylglycine, CH3NH2, N,N-Me2Thr and di-α-amino acid containing diphenylether moiety.The peptide sequence except one labile amino acid residue was determined by partial hydrolysis, chemical cleavage, and the Edman degradation.The unknown amino acid was finally deduced to be the dehydroamino acid containing epoxide, resulting in an elucidation of whole structure of the antibiotic.