AN EFFICIENT SYNTHESIS OF γ-AMINO-β-KETOALKYLPHOSPHONATES FROM α-AMINO ACIDS

Article abstract of DOI:10.1016/S0040-4039(00)95793-9

The reaction of lithium salts of dialkyl methylphosphonates with suitably protected amino acid methyl esters at low temperature, followed by removal of protecting groups in the presence of trimethylsilyl bromide provides an efficient method for the synthesis of the titled compounds.