Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

DOI: 10.1039/c8ob01558a

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Organic and Biomolecular Chemistry p. 5422 - 5426 (2018)

Update date:2022-07-30

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Authors:

Wang, Zhi-Peng

He, Yun He, Yun

Shao, Pan-Lin

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Article abstract of DOI:10.1039/c8ob01558a

Presented herein is an unprecedented transition-metal-free cyclization of methyl isocyanoacetate with aurone analogues catalyzed by NaOH. Various 2,3,4-trisubstituted pyrroles were obtained in excellent yields (up to 99%). The high efficiency of this synthetic procedure, coupled with the operational simplicity and atom economy, makes it an attractive method for the synthesis of polysubstituted pyrroles.

Full text of DOI:10.1039/c8ob01558a

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