A New Class of Photolabile Chelators for the Rapid Release of Divalent Cations: Generation of Caged Ca and Caged Mg

DOI: 10.1021/jo00244a022

Source and publish data:

Journal of Organic Chemistry p. 1966 - 1969 (1988)

Update date:2022-08-03

Topics:

Authors:

Ellis-Davies, G.C.R.

Kaplan, J.H.

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Article abstract of DOI:10.1021/jo00244a022

The synthesis of 2-nitro-4,5-dimethoxyphenyl derivatives of EGTA and EDTA is reported.These tetracarboxylate chelators are designed for the rapid photochemically initiated release of divalent cations in intact physiological systems.The key step in the synthesis is the use of high-pressure synthetic technology for the construction of the tertiary amine moiety of both types of chelator.

Full text of DOI:10.1021/jo00244a022

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