Heterocycles p. 2711 - 2716 (1987)
Update date:2022-08-04
Topics:
Stavenuiter, Johannes
Hamzink, Martin
Hulst, Rob van der
Zomer, Gijsbert
Westra, Gerard
Kriek, Erik
The coupling reaction of bromo- and iodopyridines 1 with phenylboronic acid (2a) by Pd(Ph3P)4 provides a convenient route to phenylpyridines, even when electrodonating or - withdrawing substituents are present.The method is also successful for the preparation of other phenylated N-containing heterocycles 5 as phenylquinolines and -pyridines.
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