An efficient synthesis of Platelet-Activating Factor (PAF) via 1-o-alkyl-2-o-(3-isoxazolyl)-SN-glycero-3-phosphocholine, a new PAF agonist utilization of the 3-isoxazolyloxy group as a protected hydroxyl

DOI: 10.1016/S0040-4039(00)94606-9

Source and publish data:

Tetrahedron Letters p. 699 - 702 (1990)

Update date:2022-08-04

Topics:

Authors:

Nakamura, Norio

Miyazaki, Hideki

Ohkawa, Nobuyuki

Oshima, Takeshi

Koike, Hiroyuki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)94606-9

Potent PAF agonists (R)-3a,b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy gro

Full text of DOI:10.1016/S0040-4039(00)94606-9

Products guided by the article

Product name:3-((S)-1-Hexadecyloxymethyl-2-trityloxy-ethoxy)-isoxazole

Cas No:115406-35-4

R&D Labs maybe for 115406-35-4

Yangzhou Siyu Chemical Co.,Ltd.

Contact:+86-514-87325867 13358126196

Address:Room 620 Exposition Pavilion，No. 98 Huaihai Road,Guangling District，Yangzhou City, Jiangsu Province
Cartoon Ingredients Co., Ltd

website:http://www.cartoonchem.com/

Contact:+86-25-58074918

Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Synchem Pharma Co.,Ltd(expird)

Contact:+0086-21-61984905-1

Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
Shenyang NovPharm Technology Co., Ltd.

Contact:.+86-24-24165786

Address:Room 306, Hongjin Mansion, No. 36-1, Wanliutang Rd., Shenhe District, Shenyang, Liaoning, P.R.C.

Relevant to this article

Complexation behavior of a supramolecular organic fluorophore prepared by Solid-State Co-Grinding crystallization using 2-anthraceneearboxylic acid and (R)-1-(2-Naphthyl)ethylamine and its optical properties

Doi:10.1002/ejoc.200801158
(2009)
Synthesis and photochemical behavior of μ-p-xylene-α,α'-diyldimolybdenum(II) complex

Doi:10.1016/S0022-328X(00)99801-2
(1987)
Sulfinate and Carbene Co-catalyzed Rauhut–Currier Reaction for Enantioselective Access to Azepino[1,2-a]indoles

Doi:10.1002/anie.201810879
(2019)
Asymmetric Reductive Amination of Cycloalkanones VI: Asymmetric Synthesis of cis-4aR,8aR- and cis-4aS,8aS-Decahydroquinolines

Doi:10.1002/ardp.19883210216
(1988)
Synthesis and spectroscopic studies of some cadmium(II) and mercury(II) complexes of an asymmetrical bidentate Schiff base ligand

Doi:10.1016/j.saa.2009.02.023
()
Structures of merremosides B and D, new antiserotonic resin-glycosides from the tuber of Merremia mammosa, an Indonesian folk medicine

Doi:10.1248/cpb.36.1618
(1988)

Article Doi