An efficient synthesis of Platelet-Activating Factor (PAF) via 1-o-alkyl-2-o-(3-isoxazolyl)-SN-glycero-3-phosphocholine, a new PAF agonist utilization of the 3-isoxazolyloxy group as a protected hydroxyl

DOI: 10.1016/S0040-4039(00)94606-9

Source and publish data:

Tetrahedron Letters p. 699 - 702 (1990)

Update date:2022-08-04

Topics:

Authors:

Nakamura, Norio

Miyazaki, Hideki

Ohkawa, Nobuyuki

Oshima, Takeshi

Koike, Hiroyuki

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Article abstract of DOI:10.1016/S0040-4039(00)94606-9

Potent PAF agonists (R)-3a,b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy gro

Full text of DOI:10.1016/S0040-4039(00)94606-9

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Product name:3-((S)-1-Hexadecyloxymethyl-2-trityloxy-ethoxy)-isoxazole

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