Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts

DOI: 10.1016/j.ejmech.2015.02.060

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European Journal of Medicinal Chemistry p. 163 - 174 (2015)

Update date:2022-08-03

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Authors:

Valente, Sergio

Rodriguez, Veronica

Mercurio, Ciro

Vianello, Paola

Saponara, Bruna

Cirilli, Roberto

Ciossani, Giuseppe

Labella, Donatella

Marrocco, Biagina

Monaldi, Daria

Ruoppolo, Giovanni

Tilset, Mats

Botrugno, Oronza A.

Dessanti, Paola

Minucci, Saverio

Mattevi, Andrea

Varasi, Mario

Mai, Antonello

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Article abstract of DOI:10.1016/j.ejmech.2015.02.060

The pure enantiomers of the N-(2-, 3-, and 4-(2-aminocyclopropyl)phenyl)benzamides hydrochlorides 11a-j were prepared and tested against LSD1 and MAO enzymes. The evaluation of the regioisomers 11a-j highlighted a net increase of the anti-LSD1 potency by

Full text of DOI:10.1016/j.ejmech.2015.02.060

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