STEREOSPECIFIC SYNTHESIS OF (+)-OXYBIOTIN FROM D-XYLOSE. PREPARATION OF THE FINAL CHIRAL (+)-OXYBIOTIN PRECURSOR

Article abstract of DOI:10.1016/S0040-4039(00)96827-8

A stereospecific synthesis of 2(S)-carbomethoxy-butyl-3(R),4(S)-diacetamido-tetrahydrofurane (11), the final chiral precursor in a new synthesis of (+)-oxybiotin has been achieved from 2,5-anhydro-D-xylose derivative 1.