Tetrahedron Letters p. 6675 - 6678 (1987)
Update date:2022-08-03
Topics:
Tarnchompoo, Bonkoch
Thebtaranonth, Chachanat
Thebtaranonth, Yodhathai
Diene 1 readily adds primary amines to give 2 which can cyclize either in a Michael addition fashion or via a displacement reaction to give, respectively, pyrrolidine 3 or methylene lactam 4 which further isomerizes to 5 under the employed reaction conditions.Compound 4 can be obtained as the sole product from the reaction of diene precursor 7 with amines followed by vacuum pyrolysis
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