Tetrahedron Letters p. 4182 - 4184 (2009)
Update date:2022-07-29
Topics:
Barraja, Paola
Diana, Patrizia
Montalbano, Alessandra
Martorana, Annamaria
Carbone, Anna
Cirrincione, Girolamo
A convenient synthesis of the 2-oxo-[1,4]oxazino[3,2-e]indole ring system, an heteroanalogue of Angelicin, is reported. Our synthetic approach consisted of the annelation of the oxazine ring on the indole moiety using 4-amino-5-hydroxy indoles as building blocks. The antiproliferative activity of the new compounds either in the dark or under UVA irradiation was investigated.
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