Amino Acid Derivatives That Stabilize Secondary Structures of Polypeptides. 4. Practical Synthesis of 4-(Alkylamino)-3-cyano-6-azabicyclooct-3-enes (Ben Derivatives) as γ-Turn Templates

DOI: 10.1021/jo00262a026

Source and publish data:

Journal of Organic Chemistry p. 109 - 115 (1989)

Update date:2022-07-29

Topics:

Authors:

Kemp, D.S.

Carter, Jeffery S.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00262a026

A practical synthesis of the conformationally restricted amino acid analogue methyl N-<4-<6-(benzyloxycarbonyl)-3-cyano-6-azabicyclo<3.2.1>oct-2-enyl>>-L-alaninate (12ab) from 4-hydroxyproline is described.Blocking and Barton cyanoethylation generates N-(

Full text of DOI:10.1021/jo00262a026

Products guided by the article

Product name:(2S,4S)-4-(Imidazole-1-carbothioyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Cas No:117653-40-4

R&D Labs maybe for 117653-40-4

Shanghai Send Pharmaceutical Technology Co., Ltd.

website:http://www.shsendpharma.com

Contact:021-58088081, +8613585868794

Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Shanghai Goyic Pharmaceutical&Chemical Co,. Ltd

Contact:+86-021-60275964

Address:No. 528 ruiqing road
Golden Union Agrochemical Import and Export Co., Ltd.

Contact:86-755-23910527

Address:Room 1106, Tower 3A, Excellence Century Center, Futian District, Shenzhen, China
Shanghai united Scientific Co.,Ltd.

Contact:+86-21-53535353

Address:28F No.900 huaihai Road Shanghai China
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave

Relevant to this article

Palladium catalyzed divergent cycloadditions of vinylidenecyclopropane-diesters with methyleneindolinones enabled by zwitterionic π-propargyl palladium species

Doi:10.1039/d1cc01453f
(2021)
Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas

Doi:10.1039/d1ob00728a
(2021)
Homodiphenylprolinol methyl ether as a highly efficient catalyst for asymmetric Michael addition of ketones to nitroalkenes

Doi:10.1055/s-0029-1217185
(2009)
N- and O-acylated phthalocyanines with gallic acid moieties

Doi:10.1134/S1070363216060190
(2016)
Synthese von natuerlichen Haloindolen via Hetero-Cope-Umlagerung von Vinyl-N-phenylhydroxamaten

Doi:10.1002/hlca.19880710206
(1988)
Mono-anionic acetophenone imine ligands: Synthesis, ortho-lithiation and first examples of group (v) metal complexes

Doi:10.1039/b903836a
(2009)

Article Doi