Russian Journal of Bioorganic Chemistry p. 342 - 348 (2009)
Update date:2022-08-03
Topics:
Matyugina
Alexandrova
Jasco
Ivanov
Vasiliev
Lapteva
Khandazhinskaya
Kukhanova
New non-nucleoside esters of phosphoric acid containing various hydrophobic groups, namely (1) N-(2-tripticencarbonyl)-4-aminobutyl; (2) 5-phenylsubstituted N-(2,4-dinitrophenyl)-4-aminobutyl; (3) N-(4-phenylbenzoyl)- and N-(4-(N-benzylamino)benzoyl)-2-aminoethyl groups, as well as (4) diphenylmethyl and fluorenyl groups were synthesized and studied as substrates of terminal deoxynucleotidyl transferase. With the exception of the two latter derivatives, all the analogues displayed substrate properties and could incorporate into the deoxyoligonucleotide 3′-end. As it was shown in biochemical experiments and by computer modeling, a linker joining the triphosphate and hydrophobic fragments of the molecule was necessary for these compounds to display substrate properties.
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Doi:10.1246/cl.2009.570
(2009)Doi:10.1039/b815891f
(2008)Doi:10.3987/COM-09-11690
(2009)Doi:10.1055/s-0029-1217016
(2009)Doi:10.1021/jo101439h
(2010)Doi:10.1016/S0040-4020(01)85983-4
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