European Journal of Medicinal Chemistry p. 373 - 378 (1988)
Update date:2022-08-03
Topics:
Abou-Gharbia, Magid
Patel, Usha
Tokolics, Joseph
Freed, Meier
A series of novel functionalized cycloalkaneindoles were synthesized and tested for potential anti-arrhythmic activity.Several compounds displayed moderate activity in the coronary ligated rat artery model.Carbamate 22 and the amino derivative 27 were the most potent analogs.Their anti-arrhythmic activity at a dose of 10 mg/kg, i.v., was greater than that of iprindole and ethmosin. anti-arrhythmic agents / ethmosin / carbamates / coronary ligated rats
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