SYNTHESIS AND ANTI-ARRHYTHMIC ACTIVITY OF CYCLOALKANEINDOLES

DOI: 10.1016/0223-5234(88)90211-5

Source and publish data:

European Journal of Medicinal Chemistry p. 373 - 378 (1988)

Update date:2022-08-03

Topics:

Authors:

Abou-Gharbia, Magid

Patel, Usha

Tokolics, Joseph

Freed, Meier

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Article abstract of DOI:10.1016/0223-5234(88)90211-5

A series of novel functionalized cycloalkaneindoles were synthesized and tested for potential anti-arrhythmic activity.Several compounds displayed moderate activity in the coronary ligated rat artery model.Carbamate 22 and the amino derivative 27 were the most potent analogs.Their anti-arrhythmic activity at a dose of 10 mg/kg, i.v., was greater than that of iprindole and ethmosin. anti-arrhythmic agents / ethmosin / carbamates / coronary ligated rats

Full text of DOI:10.1016/0223-5234(88)90211-5

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