Direct enantiomeric separation of platelet-activating factor receptor antagonist SM-10661 by ligand-exchange high-performance liquid chromatography with a copper (II) N,S-dioctyl-D-penicillamine complex.

Article abstract of DOI:10.1271/bbb.59.1740

The enantiomeric separation of SM-10661, a platelet activating factor receptor antagonist, was investigated by HPLC using ligand-exchange chiral stationary phases. The stereoisomers of SM-10661 could all be separated by ligand-exchange HPLC with a Cu(II) N,S-dioctyl-D-penicillamine complex (Sumichiral OA-5000). The mechanism for the resolution includes the involvement of hydrophobic interactions between SM-10661 and Cu(II) D-penicillamine.

Full text of DOI:10.1271/bbb.59.1740

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Bioscience, Biotechnology, and Biochemistry
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Direct Enantiomeric Separation of Platelet-activating
Factor Receptor Antagonist SM-10661 by Ligand-
exchange High-performance Liquid Chromatography
with a Copper(II) N,S-Dioctyl-D-penicillamine
Complex
Masahiko Okamotoa, Youichi Uedaa, Ken-ichi Takahashia, Hiroshi Nakazawaa & Tadashi
Doia
a Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 1–98, 3-
chome, Kasugade-naka, Konohana-ku, Osaka 554, Japan
Published online: 12 Jun 2014.
To cite this article: Masahiko Okamoto, Youichi Ueda, Ken-ichi Takahashi, Hiroshi Nakazawa & Tadashi Doi (1995)
Direct Enantiomeric Separation of Platelet-activating Factor Receptor Antagonist SM-10661 by Ligand-exchange High-
performance Liquid Chromatography with a Copper(II) N,S-Dioctyl-D-penicillamine Complex, Bioscience, Biotechnology,
and Biochemistry, 59:9, 1740-1741, DOI: 10.1271/bbb.59.1740
To link to this article: http://dx.doi.org/10.1271/bbb.59.1740
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