Journal of the Chemical Society. Chemical communications p. 1610 - 1612 (1988)
Update date:2022-08-03
Topics:
Bycroft, Barrie W.
Gledhill, Linden
Shute, Richard E.
Williams, Paul
The chlorinated 6-spiroepoxypenicillin anilides (1a) and (1b) are irreversible inhibitors of β-lactamase I from Bacillus cereus, but they are also turned over by this enzyme to yield the same hydrolysis product, whose structure has been revealed to be an unusual 6-substituted-1,4-dihydrothiazine-3-carboxylate, α-ketoamide; a possible pathway for the turnover and inhibitory processes associated with these interactions is presented.
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