Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1,6] naphthyridines at α-adrenoceptors

DOI: 10.1021/jm00106a036

Source and publish data:

Journal of Medicinal Chemistry p. 705 - 717 (1991)

Update date:2022-08-05

Topics:

Authors:

Clark Clark

Repke Repke

Berger Berger

Nelson Nelson

Kilpatrick

Brown Brown

MacKinnon

Clague Clague

Spedding

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Article abstract of DOI:10.1021/jm00106a036

Analogues of the potent α₂-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12- (methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine (1b) were prepared and evaluated for α₁- and α₂-

Full text of DOI:10.1021/jm00106a036

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Product name:4-[(7aS,11aR,12aR)-(5,7a,8,9,10,11a,12,12a-Octahydro-6H,7H-6a,11-diaza-benzo[a]anthracen-11-yl)sulfonyl]-phenylamine

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