Bioorganic and Medicinal Chemistry Letters p. 256 - 259 (2010)
Update date:2022-08-04
Topics:
Miller, John F.
Turner, Elizabeth M.
Sherrill, Ronald G.
Gudmundsson, Kristjan
Spaltenstein, Andrew
Sethna, Phiroze
Brown, Kevin W.
Harvey, Robert
Romines, Karen R.
Golden, Pamela
The identification and optimization of a series of substituted tetrahydro-β-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the β-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.
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